← Statins × cardiovascular events

SynthesisScientific reports2015

The effect of statins on chronic obstructive pulmonary disease exacerbation and mortality: a systematic review and meta-analysis of observational research.

Chao Cao et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 238,459 people · 2015

Not counted

Lowered adverse events & safety

−36%−45% to −25%

Bigger than 7 in 10 for adverse events & safety

As reported

HR 0.64, 95% CI 0.55–0.75

Not counted

Lowered adverse events & safety

−36%−45% to −25%

Bigger than 7 in 10 for adverse events & safety

As reported

HR 0.64, 95% CI 0.55–0.75

Not counted

Reduced deaths

−38%−48% to −27%

Bigger than 9 in 10 for all-cause mortality

As reported

HR 0.62, 95% CI 0.52–0.73 · the paper's word: All-cause mortality

What moved togetherboth groups pooled, not the treatment’s effect

Correlation · may be no link

No clear link with adverse events & safety

−17%−35% to +8%

Bigger than 5 in 10 for adverse events & safety

As reported

HR 0.83, 95% CI 0.65–1.08

Correlation, not cause

Went with fewer cardiovascular events

−31%−51% to −1%

Bigger than 7 in 10 for cardiovascular events

As reported

HR 0.69, 95% CI 0.49–0.99

Five numbers in the abstract

the abstract, start to end

… of cancer mortality was observed (HR 0.83, 95% CI 0.65 to 1.08; …

… risk of myocardial infarction (HR 0.69, 95% CI 0.49 to 0.99).

… lower risk of mild COPD exacerbation (HR 0.64, 95% CI 0.55 to 0.75) and a …

… with or without hospitalization (HR 0.64, 95% CI 0.55 to 0.75; Fig. 3).

… in the statin-unexposed group (HR 0.62, 95% CI 0.52 to 0.73; Fig. 2).

← favours treatmentfavours comparator →
could be chance
Adverse events & safety
HR 0.830.65–1.08
Cardiovascular events
HR 0.690.49–0.99
Adverse events & safety
HR 0.640.55–0.75
Adverse events & safety
HR 0.640.55–0.75
All-cause mortality
HR 0.620.52–0.73
StatinsCardiovascular eventsAll-cause mortalityAdverse events & safety
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Full record →Abstract, authors, funding and every citing paper · PMID 26553965