Evidence map›Paper›PMID 21818123›Full record

ArticleNature reviews. Immunology2011

The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease.

Michael Gleeson, Nicolette C Bishop, David J Stensel, Martin R Lindley, Sarabjit S Mastana, Myra A Nimmo

5 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Nature reviews. Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 1,183 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,183citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04122716 phase4unknown statusstarted 2016, after this paper: background citation

Synergy Effect of the Appetite Hormone GLP-1 (LiragluTide) and Exercise on Maintenance of Weight Loss and Health After a Low Calorie Diet - the S-LiTE Randomized Trial

Ran2016Enrolled215Registered outcomes28Posted comparisons0ConditionsObesityArmsExercise, liraglutide
PMID 23186644PMID 26132939PMID 26284720PMID 28049736PMID 30052921PMID 27295427PMID 27633186PMID 25287751PMID 23812094PMID 12626436PMID 16464906PMID 16476868other papers from this trial
Open the trial in the graph
NCT04436419 nacompletednot on this mapstarted 2018, after this paper: background citation

Immunometabolic Effects of Non-drug Strategies in the Clinical Management of Obesity: Translational Study

TypeinterventionalSponsorFauquéRan2018 to 2020Enrolled40ConditionsObesity, Obesity, Abdominal, Obesity, Visceral, FemaleArmsAlpha lipoic acid (plus full hospitalization), Placebo (full hospitalization: dietary monitoring with an adapted physical activity program)
NCT06669702 narecruitingnot on this mapstarted 2024, after this paper: background citation

EXercise As an Anti-inflammatory Treatment in Axial Spondyloarthritis (axSpA) for Patients Taking Biologic Therapy: a Proof of Concept Study (ExTASI-B).

TypeinterventionalSponsorLoughborough UniversityRan2024 to 2029Enrolled60ConditionsAxial Spondyloarthrithis, Inflammatory Diseases, ArthritisArms12-week home based exercise, Routine care
NCT06987708 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluating the Impact of a 12-month Multi-Modal Lifestyle Management Intervention on Disease Relevant Biomarkers Associated With Monoclonal Gammopathy of Unknown Significance (MGUS) and Smoldering Myeloma (SM): A Prospective Intervention Pilot Study

TypeinterventionalSponsorHackensack Meridian HealthRan2026 to 2028Enrolled67ConditionsMonoclonal Gammopathy of Uncertain Significance, Smoldering MyelomaArmsThe Multimodal Lifestyle Intervention
NCT07484776 naactive not recruitingnot on this mapstarted 2026, after this paper: background citation

Metabolic Flexibility in Patients With Early Triple-negative Breast Cancer and the Possible Effect of a Physical Exercise Intervention

TypeinterventionalSponsorUniversidad Europea de MadridRan2026 to 2028Enrolled40ConditionsTriple-Negative Breast Cancer (TNBC)ArmsCardiovascular training at maximal fat oxidation (FATmax), Cardiovascular training at maximal aerobic power (MAP), Resistance training
3 · Its place in the literature

Who cites it

1,183 citing papers in PubMed, 18 syntheses or guidelines pooled it.

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1,123 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael GleesonInflammation, Exercise and Metabolism Research Group, School of Sport, Exercise and Health Sciences, Loughborough University, Ashby Road, Loughborough, Leicestershire LE11 3TU, UK. M.Gleeson@lboro.ac.uk
Nicolette C Bishop
David J Stensel
Martin R Lindley
Sarabjit S Mastana
Myra A Nimmo

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regular exercise reduces the risk of chronic metabolic and cardiorespiratory diseases, in part because exercise exerts anti-inflammatory effects. However, these effects are also likely to be responsible for the suppressed immunity that makes elite athletes more susceptible to infections. The anti-inflammatory effects of regular exercise may be mediated via both a reduction in visceral fat mass (with a subsequent decreased release of adipokines) and the induction of an anti-inflammatory environment with each bout of exercise. In this Review, we focus on the known mechanisms by which exercise - both acute and chronic - exerts its anti-inflammatory effects, and we discuss the implications of these effects for the prevention and treatment of disease.

Indexed as

AdipokinesAnimalsAthletesCytokinesEpinephrineExerciseHumansHydrocortisoneImmune SystemInflammation MediatorsLipidsMiceObesityToll-Like ReceptorsAdipokinesCytokinesEpinephrineHydrocortisoneInflammation MediatorsLipidsToll-Like Receptors

Identifiers

PMID21818123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.