Evidence map›Paper›PMID 21698507›Full record

ArticleNeurotoxicity research2011

Neuroprotective effects of white tea against oxidative stress-induced toxicity in striatal cells.

M P Almajano, I Vila, S Gines

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. White Peony (FermentedAntioxidants (Basel, Switzerland) · 2019
    Article
  8. Article
  9. Article
  10. Article
  11. Molecular mechanisms by which white tea prevents oxidative stress.Journal of physiology and biochemistry · 2014
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

M P AlmajanoChemistry Engineering Department, The Technical University of Catalonia, Av. Diagonal 649, 08034 Barcelona, Spain.
I Vila
S Gines
Biomedical Research Networking Center on Neurodegenerative Diseases · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESUniversitat Politècnica de Catalunya · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tea is one of the most widely consumed beverages in the world and represents an important source of antioxidants mainly catechins that confer beneficial effects in reducing the risk of cardiovascular diseases, age-related disorders or cancer. In the central nervous system, oxidative stress caused by increased production of reactive oxygen and nitrogen species represents an important mechanism for neuronal dysfunction and cell loss in different neurodegenerative disorders. The neuroprotective effects of green-tea-derived polyphenols have extensively been demonstrated in different models of neurotoxicity. However, few data have been reported on the antioxidant activity of white tea extracts in the nervous system. In the present study, we demonstrate that white tea extracts protect striatal cell lines against oxidative stress-mediated cell death. The effects of white tea on protection of striatal cell cultures are likely associated with the antioxidant properties of white tea components since neuronal cell loss induced by nonoxidative insults such as D1 dopamine receptor activation cannot be prevented by pre-treatment with white tea. Altogether our results suggest that regular consumption of white tea may contribute to reduce oxidative stress associated with brain injury and be clinically useful for treating age-related and neurodegenerative disorders.

Indexed as

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAnimalsBiflavonoidsCaffeineCatechinCell LineCell SurvivalDopamine AgonistsDose-Response Relationship, DrugDrug InteractionsHumansHydrogen PeroxideMiceNeuroprotective AgentsOxidantsOxidative Stress2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineBiflavonoidsCaffeineCatechinDopamine AgonistsHydrogen PeroxideNeuroprotective AgentsOxidantsPlant ExtractsPolyphenolsReceptors, Dopamine D1TeaTECAtheaflavinTriterpenes

Identifiers

PMID21698507
OpenAlexW2038825017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.