ReviewAmerican journal of physiology. Endocrinology and metabolism2011
Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature.
Review in American journal of physiology. Endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 108 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome
Effect of GLP-1 on Microvascular Insulin Responses in Type 1 Diabetes
Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome
Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes
The Effect of Type 1 Diabetes on Pan-Arterial Vascular Function and Insulin Sensitivity in Humans
The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 Diabetes
Impact of Acute Exercise on Vascular Insulin Sensitivity in Metabolic Syndrome
Who cites it
108 citing papers in PubMed, 168 citations in OpenAlex.
- Effects of a high-fat meal on inflammatory and endothelial injury biomarkers in accordance with adiposity status: a cross-sectional study.Nutrition journal · 2022Trial
- Acute hyperglycaemia enhances both vascular endothelial function and cardiac and skeletal muscle microvascular function in healthy humans.The Journal of physiology · 2022Trial
- Improving Peripheral and Central Vascular Adjustments during Exercise through a Training Program in Adolescents with Obesity.Obesity facts · 2016Trial
- Trial
- Therapeutic Modulation of Nitric Oxide Pathways to Address Insulin Resistance in Cardiovascular-Kidney-Metabolic Syndrome.International journal of molecular sciences · 2026Review
- Contrast enhanced ultrasound and laser doppler flowmetry capture distinct aspects of tissue microvascular perfusion in nonhuman primates.Physiological reports · 2026Article
- A full-length single nuclei transcriptomic atlas of human skeletal muscle insulin resistance.bioRxiv : the preprint server for biology · 2026Article
- Postmeal walking reduces nighttime central SBP and increases nocturnal dipping of SBP in healthy, physically inactive young women.Journal of hypertension · 2025Article
- Unraveling Skeletal Muscle Insulin Resistance: Molecular Mechanisms and the Restorative Role of Exercise.Circulation research · 2025Review
- Interplay of fatty acids, insulin and exercise in vascular health.Lipids in health and disease · 2025Review
- Association between metabolic health indicators and cardiorespiratory fitness in urban young and middle-aged population: a retrospective cross-sectional study.Frontiers in endocrinology · 2025Article
- Endothelial β1-integrins are necessary for microvascular function and glucose uptake.American journal of physiology. Endocrinology and metabolism · 2024Article
- Prazosin improves insulin-induced anabolic signaling by protecting capillary regression in the soleus muscle of hindlimb-unloaded rats.Journal of diabetes and metabolic disorders · 2024Article
- Review
- Endothelial β1 Integrins are Necessary for Microvascular Function and Glucose Uptake.bioRxiv : the preprint server for biology · 2024Article
- Ethnicity-related differences in mitochondrial regulation by insulin stimulation in diabetes.Journal of cellular physiology · 2024Review
- Empagliflozin improves vascular insulin sensitivity and muscle perfusion in persons with type 2 diabetes.American journal of physiology. Endocrinology and metabolism · 2024Article
- The WCIRDC 2023: Concepts of insulin resistance.Journal of diabetes · 2024Article
- Article
- Microvascular Skeletal-Muscle Crosstalk in Health and Disease.International journal of molecular sciences · 2023Review
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Insulin, at physiological concentrations, regulates the volume of microvasculature perfused within skeletal and cardiac muscle. It can also, by relaxing the larger resistance vessels, increase total muscle blood flow. Both of these effects require endothelial cell nitric oxide generation and smooth muscle cell relaxation, and each could increase delivery of insulin and nutrients to muscle. The capillary microvasculature possesses the greatest endothelial surface area of the body. Yet, whether insulin acts on the capillary endothelial cell is not known. Here, we review insulin's actions at each of three levels of the arterial vasculature as well as recent data suggesting that insulin can regulate a vesicular transport system within the endothelial cell. This latter action, if it occurs at the capillary level, could enhance insulin delivery to muscle interstitium and thereby complement insulin's actions on arteriolar endothelium to increase insulin delivery. We also review work that suggests that this action of insulin on vesicle transport depends on endothelial cell nitric oxide generation and that insulin's ability to regulate this vesicular transport system is impaired by inflammatory cytokines that provoke insulin resistance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.