Evidence map›Paper›PMID 21178985›Full record

ArticleClinical pharmacology and therapeutics2011

Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: a go-DARTS study.

L A Donnelly, A S F Doney, R Tavendale, C C Lang, E R Pearson, H M Colhoun, M I McCarthy, A T Hattersley, A D Morris, C N A Palmer

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical pharmacology and therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02783469 (Genetics of Diabetes Audit and Research in Tayside Scotland), which is not on this map. Cited by 86 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 13 pooled it
17.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02783469 completednot on this map

Genetics of Diabetes Audit and Research in Tayside Scotland (DOLORisk Dundee)

TypeobservationalSponsorUniversity of DundeeRan2004 to 2009Enrolled1,915ConditionsDiabetic Neuropathic PainArmsIdentification of genetic causes of diabetic neuropathic pain
3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 13 syntheses or guidelines pooled it, 205 citations in OpenAlex.

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  8. Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis.Drug metabolism and disposition: the biological fate of chemicals · 2016
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  10. Genetic factors affecting statin concentrations and subsequent myopathy: a HuGENet systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2014
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  20. Evaluating genotype-treatment interactions for high-risk medications in British general practice: a retrospective cohort study using UK Biobank.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026
    Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

L A DonnellyPopulation Pharmacogenetics Group and Diabetes Research Centre, Biomedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
A S F Doney
R Tavendale
C C Lang
E R Pearson
H M Colhoun
M I McCarthy
A T Hattersley
A D Morris
C N A Palmer
Ninewells Hospital · GBUniversity of Dundee · GBPeninsula College of Medicine and Dentistry · GBUniversity of Oxford · GB

Funding

Medical Research Council G0601261Wellcome Trust 072960Wellcome Trust 084726
6 · The paper itself

Abstract

SLCO1B1 gene variants are associated with severe statin-induced myopathy. We examined whether these variants are also associated with general statin intolerance in a large population of patients with type 2 diabetes receiving statins as part of routine clinical care. A total of 4,196 individuals were genotyped for rs4149056 (Val174Ala) and rs2306283 (Asp130Asn). Intolerance was defined by serum biochemistry and also by discontinuation, switching, or reduction in dose of the prescribed statin drug. Ala174 was associated with higher intolerance (odds ratio = 2.05, P = 0.043), whereas Asp130 was associated with lower intolerance (odds ratio = 0.71, P = 0.026). Ala174 was associated with a lower low-density lipoprotein cholesterol (LDLc) response to statins (P = 0.01) whereas 130D was associated with a greater LDLc response to statins (P = 0.048), as previously reported; however, this association was no longer present when data for statin-intolerant individuals were removed from the analysis. This study suggests that common genetic variants selected for an extreme phenotype of statin-induced myopathy also predispose to more common milder statin intolerance and may, for this reason, impact lipid-lowering efficacy.

Indexed as

AgedCholesterol, LDLDiabetes Mellitus, Type 2FemaleGenotypeHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLiver-Specific Organic Anion Transporter 1Logistic ModelsMaleMiddle AgedOrganic Anion TransportersCholesterol, LDLHydroxymethylglutaryl-CoA Reductase InhibitorsLiver-Specific Organic Anion Transporter 1Organic Anion TransportersSLCO1B1 protein, human

Identifiers

PMID21178985
PMCPMC3353487
OpenAlexW2167980243

What OpenQuestion holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.