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SynthesisPharmacogenetics and genomics2013

Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment.

Louise A Donnelly et al.PubMed ↗Full text ↗Publisher ↗

  • G allele of rs10455872looks bad hereHigher LDLc in response to statin treatment.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

G allele of rs10455872 went with higher LDLc in response to statin treatment

+0.10mmol/l

G allele of rs10455872 vs non-G allele (implied)

As reported

difference 0.10 mmol/l, no interval · the paper's word: reduction in LDLc in response to statin treatment

Who was studied, and how

8,822people with dyslipidemia, in this paper

Already taking G allele of rs10455872, or nottheir own situation, not assigned

on G allele of rs10455872
not on G allele (implied)

G allele of rs10455872 went with higher LDLc in response to statin treatment+0.10

correlation, not a test

the abstract, start to end

… of rs10455872 being associated with a 0.10 mmol/l per allele poorer …

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
Reduction in LDLc in response to statin treatmentG allele of rs10455872 vs non-G allele (implied)
0.10
Investigational compoundsLipids
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10 papers cite it

2013
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this paperpooled itcites it

The trial

Full record →Abstract, authors, funding and every citing paper · PMID 23903772