Evidence map›Paper›PMID 21063014›Full record

ArticleJAMA2010

Association of adolescent obesity with risk of severe obesity in adulthood.

Natalie S The, Chirayath Suchindran, Kari E North, Barry M Popkin, Penny Gordon-Larsen

2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph

Article in JAMA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 197 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
197citing papers in PubMed, 12 pooled it
37.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05574439 phase4completedstarted 2022, after this paper: background citation

Young Adults With Early-onset Obesity Treated With Semaglutide -The RESETTLE Study

Ran2022Enrolled246Registered outcomes54Posted comparisons0ConditionsObesity, AdolescentArmsPlacebo (Semaglutide 3 mg/ml), Semaglutide 3 mg/ml, TCOC treatment
Open the trial in the graph
NCT06067451 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Impact of SMART GOAL Setting Protocol on Body Weight and Metabolic Parameters in Children and Adolescents With Prediabetes; a Randomized Clinical Trial.

TypeinterventionalSponsorNorthwell HealthRan2023 to 2025Enrolled80ConditionsPreDiabetes, Adolescent Obesity, Behavior, Health, Nutritional and Metabolic DiseasesArmsSMART GOALS Setting Tool/ Protocol
3 · Its place in the literature

Who cites it

197 citing papers in PubMed, 12 syntheses or guidelines pooled it, 454 citations in OpenAlex.

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  4. Overweight and Obesity in Patients with Congenital Heart Disease: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  5. A systematic review and meta-analysis estimating the population prevalence of comorbidities in children and adolescents aged 5 to 18 years.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019
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  13. Physical Activity Levels and Screen Time among Youth with Overweight/Obesity Using Mental Health Services.International journal of environmental research and public health · 2022
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137 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Natalie S TheDepartments of Nutrition, Carolina Population Center, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27516-3997, USA.
Chirayath Suchindran
Kari E North
Barry M Popkin
Penny Gordon-Larsen
Department of Health · ZA

Funding

Wave IV Data CollectionP01HD031921 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 1994 to 2020
$86.1M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
Carolina Population CenterR24HD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORGAN, SAMUEL PHILIP · 2005 to 2014
$10.0M
Gene-Environment Interactions and Weight GainR01HD057194 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GORDON-LARSEN, PENNY, NORTH, KARI E. · 2008 to 2019
$5.9M
NICHD NIH HHS P01 HD031921NICHD NIH HHS P01-HD31921NICHD NIH HHS R01 HD057194NICHD NIH HHS R01-HD057194NICHD NIH HHS R24 HD050924NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

contextAlthough the prevalence of obesity has increased in recent years, individuals who are obese early in life have not been studied over time to determine whether they develop severe obesity in adulthood, thus limiting effective interventions to reduce severe obesity incidence and its potentially life-threatening associated conditions.

objectiveTo determine incidence and risk of severe obesity in adulthood by adolescent weight status. DESIGN, SETTING, AND

participantsA cohort of 8834 individuals aged 12 to 21 years enrolled in 1996 in wave II of the US National Longitudinal Study of Adolescent Health, followed up into adulthood (ages 18-27 years during wave III [2001-2002] and ages 24-33 years during wave IV [2007-2009]). Height and weight were obtained via anthropometry and surveys administered in study participants' homes using standardized procedures.

main outcome measuresNew cases of adult-onset severe obesity were calculated by sex, race/ethnicity, and adolescent weight status. Sex-stratified, discrete time hazard models estimated the net effect of adolescent obesity (aged <20 years; body mass index [BMI] ≥95th percentile of the sex-specific BMI-for-age growth chart or BMI ≥30.0) on risk of severe obesity incidence in adulthood (aged ≥20 years; BMI ≥40.0), adjusting for race/ethnicity and age and weighted for national representation.

resultsIn 1996, 79 (1.0%; 95% confidence interval [CI], 0.7%-1.4%) adolescents were severely obese; 60 (70.5%; 95% CI, 57.2%-83.9%) remained severely obese in adulthood. By 2009, 703 (7.9%; 95% CI, 7.4%-8.5%) non-severely obese adolescents had become severely obese in adulthood, with the highest rates for non-Hispanic black women. Obese adolescents were significantly more likely to develop severe obesity in young adulthood than normal-weight or overweight adolescents (hazard ratio, 16.0; 95% CI, 12.4-20.5).

conclusionIn this cohort, obesity in adolescence was significantly associated with increased risk of incident severe obesity in adulthood, with variations by sex and race/ethnicity.

Indexed as

AdolescentAdultAge of OnsetBody WeightChildCohort StudiesFemaleHumansIncidenceMaleObesityRacial GroupsRiskSeverity of Illness IndexSex FactorsUnited States

Identifiers

PMID21063014
PMCPMC3076068
OpenAlexW2059106770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.