ArticleCell stress & chaperones2011
The protective role of 5-HMF against hypoxic injury.
Article in Cell stress & chaperones, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Evaluation of Wound Healing Potential of (5-formylfuran-2-yl)Methyl Benzoates byTurkish journal of pharmaceutical sciences · 2026Article
- Structural and energetic basis of marine phytochemicals as dengue NS1 protein inhibitors.Scientific reports · 2025Article
- The Physicochemical, Nutritional, and Antioxidative Properties of Plant-Based Quinoa Yogurt.Food science & nutrition · 2025Article
- The antisickling agent, 5-hydroxymethyl-2-furfural: Other potential pharmacological applications.Medicinal research reviews · 2024Review
- Associations of 10 dietary habits with breast cancer: a Mendelian randomization study.Frontiers in nutrition · 2023Article
- Phytochemical Composition and Bioactivities of Aqueous Extract of Rambutan (Antioxidants (Basel, Switzerland) · 2022Article
- Phytochemical Profiling ofPlants (Basel, Switzerland) · 2022Article
- Electrochemical Determination of the "Furanic Index" in Honey.Molecules (Basel, Switzerland) · 2021Article
- Comprehensive Metabolomics and Network Pharmacology to Explore the Mechanism of 5-Hydroxymethyl Furfural in the Treatment of Blood Deficiency Syndrome.Frontiers in pharmacology · 2021Article
- Anti-microbial and anti-inflammatory effects of Cheonwangbosim-dan againstJournal of veterinary science · 2020Article
- Changes of 5-hydroxymethyl-2-furfural in fresh and processed ginsengs.Food science & nutrition · 2020Article
- 5-Hydroxymethylfurfural (HMF) levels in honey and other food products: effects on bees and human health.Chemistry Central journal · 2018Review
- 5-HMF attenuates striatum oxidative damage via Nrf2/ARE signaling pathway following transient global cerebral ischemia.Cell stress & chaperones · 2017Article
- New developments in anti-sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?British journal of haematology · 2016Review
- Enhanced hypoxia-inducible factor (HIF)-1α stability induced by 5-hydroxymethyl-2-furfural (5-HMF) contributes to protection against hypoxia.Molecular medicine (Cambridge, Mass.) · 2015Article
- Ameliorative effects of 5-hydroxymethyl-2-furfural (5-HMF) from Schisandra chinensis on alcoholic liver oxidative injury in mice.International journal of molecular sciences · 2015Article
- Arsenic trioxide reduces chemo-resistance to 5-fluorouracil and cisplatin in HBx-HepG2 cells via complex mechanisms.Cancer cell international · 2015Article
- 5-hydroxymethyl-2-furfural prolongs survival and inhibits oxidative stress in a mouse model of forebrain ischemia.Neural regeneration research · 2012Article
- The protective role of 5-hydroxymethyl-2-furfural (5-HMF) against acute hypobaric hypoxia.Cell stress & chaperones · 2011Article
- Efficacy of Oral Curcuminoid Fraction from Curcuma xanthorrhiza and Curcuminoid Cider in High-cholesterol Fed Rats.Pharmacognosy researchArticle
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an attempt to find new types of anti-hypoxic agents from herbs, we identified 5-hydroxymethyl-2-furfural (5-HMF) as a natural agent that fulfills the criterion. 5-HMF, the final product of carbohydrate metabolism, has favorable biological effects such as anti-oxidant activity and inhibiting sickling of red blood cells. The role of 5-HMF in hypoxia, however, is not yet. Our pilot results showed that pretreatment with 5-HMF markedly increased both the survival time and the survival rate of mice under hypoxic stress. The present study was aimed to further investigate the protective role of 5-HMF and the underlying mechanisms in hypoxic injury using ECV304 cells as an in vitro model. ECV304 cells pretreated with or without 5-HMF for 1 h were exposed to hypoxic condition (0.3% O(2)) for 24 h and then cell apoptosis, necrosis, the changes of mitochondrial membrane potential (MMP) and the expressions of phosphorylation- extracellular signal-regulated kinase (p-ERK) were investigated. Pretreatment with 5-HMF markedly attenuated hypoxia-induced cell necrosis and apoptosis at late stage (p < 0.01). Furthermore, pretreatment with 5-HMF rescued both the decline of the MMP and the increase of p-ERK protein under hypoxia. In a word, these results indicated that 5-HMF had protective effects against hypoxic injury in ECV304 cells, and its effects on MMP and p-ERK may be involved in the mechanism.
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