ReviewCurrent atherosclerosis reports2010
Revisiting dietary cholesterol recommendations: does the evidence support a limit of 300 mg/d?
Review in Current atherosclerosis reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 56 citations in OpenAlex.
- The effects of a high protein diet on indices of health and body composition--a crossover trial in resistance-trained men.Journal of the International Society of Sports Nutrition · 2016Trial
- Effect of Various Types of Heat Processing on the Content and Retention of Fat-Soluble Vitamins and Cholesterol in Goose Breast Meat.Foods (Basel, Switzerland) · 2025Article
- Does eating eggs matter?Archives of endocrinology and metabolism · 2022Review
- Cholesterol Content, Fatty Acid Profile and Health Lipid Indices in the Egg Yolk of Eggs from Hens at the End of the Laying Cycle, Following Alpha-Ketoglutarate Supplementation.Foods (Basel, Switzerland) · 2021Article
- Article
- Article
- Dairy Fats and Cardiovascular Disease: Do We Really Need to be Concerned?Foods (Basel, Switzerland) · 2018Review
- A High Protein Diet Has No Harmful Effects: A One-Year Crossover Study in Resistance-Trained Males.Journal of nutrition and metabolism · 2016Article
- Egg phospholipids and cardiovascular health.Nutrients · 2015Review
- A Snack Dietary Pattern Increases the Risk of Hypercholesterolemia in Northern Chinese Adults: A Prospective Cohort Study.PloS one · 2015Article
- Milk, dairy products, and their functional effects in humans: a narrative review of recent evidence.Advances in nutrition (Bethesda, Md.) · 2014Review
- Egg consumption and cardiovascular disease among diabetic individuals: a systematic review of the literature.Diabetes, metabolic syndrome and obesity : targets and therapy · 2014Review
- Limitations of observational evidence: implications for evidence-based dietary recommendations.Advances in nutrition (Bethesda, Md.) · 2014Review
- Predicting the impact of diet and enzymopathies on human small intestinal epithelial cells.Human molecular genetics · 2013Article
- Exploring the factors that affect blood cholesterol and heart disease risk: is dietary cholesterol as bad for you as history leads us to believe?Advances in nutrition (Bethesda, Md.) · 2012Article
- Review
- Short chain saturated fatty acids decrease circulating cholesterol and increase tissue PUFA content in the rat.Lipids · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The perceived association between dietary cholesterol (DC) and risk for coronary heart disease (CHD) has resulted in recommendations of no more than 300 mg/d for healthy persons in the United States. These dietary recommendations proposed in the 1960s had little scientific evidence other than the known association between saturated fat and cholesterol and animal studies where cholesterol was fed in amounts far exceeding normal intakes. In contrast, European countries, Asian countries, and Canada do not have an upper limit for DC. Further, current epidemiologic data have clearly demonstrated that increasing concentrations of DC are not correlated with increased risk for CHD. Clinical studies have shown that even if DC may increase plasma low-density lipoprotein (LDL) cholesterol in certain individuals (hyper-responders), this is always accompanied by increases in high-density lipoprotein (HDL) cholesterol, so the LDL/HDL cholesterol ratio is maintained. More importantly, DC reduces circulating levels of small, dense LDL particles, a well-defined risk factor for CHD. This article presents recent evidence from human studies documenting the lack of effect of DC on CHD risk, suggesting that guidelines for DC should be revisited.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.