Evidence map›Paper›PMID 20339920›Full record

SynthesisThe international journal of cardiovascular imaging2010

Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis.

Yoichi Inaba, Jennifer A Chen, Steven R Bergmann

5 registry-linked trialsAbstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in The international journal of cardiovascular imaging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 359 papers, 36 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
359citing papers in PubMed, 36 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03309618 nacompletedstarted 2012, after this paper: background citation

Improving Arterial Wall Characteristics in Patients After Myocardial Infarction With a Very Low Dose of Fluvastatin and Valsartan: Proof-of-concept Study

Ran2012Enrolled36Registered outcomes10Posted comparisons0ConditionsMyocardial InfarctionArmslow-dose combination of fluvastatin (10 mg) and valsartan (20 mg) (low-flu/val), Placebo
PMID 28012835PMID 22385885PMID 12588755PMID 15452025PMID 20338492PMID 10913483PMID 10666353PMID 21127698PMID 26214555PMID 28384560other papers from this trial
Open the trial in the graph
NCT05478707 phase2recruitingstarted 2023, after this paper: background citation

Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes

Ran2023Enrolled47Registered outcomes5Posted comparisons0ConditionsDiabetes Mellitus, Type 1, Endothelial DysfunctionArmsDulaglutide, Placebo
PMID 29310645PMID 24742660PMID 22732108PMID 27295427PMID 27436611PMID 27633186PMID 29371269PMID 17711996PMID 19654321PMID 19672102PMID 20739685PMID 20952670other papers from this trial
Open the trial in the graph
NCT03881943 phase4completednot on this mapstarted 2017, after this paper: background citation

A Randomized, Single Center Trial to Assess the Endothelial Function With Ticagrelor Monotherapy Compared to Aspirin Monotherapy in Patients With History of Acute Coronary Syndrome

TypeinterventionalSponsorThe University of Hong KongRan2017 to 2018Enrolled200ConditionsAcute Coronary SyndromeArmsTicagrelor 60 mg, Aspirin 100 MG Oral Tablet, Enteric Coated
NCT04371757 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Influence of the Autonomic Nervous System on Endothelial Function as an Acute Response to Exercise in Hypertensive Individuals: a Randomized Double-blind Protocol Study

TypeinterventionalSponsorInstituto de Cardiologia do Rio Grande do SulRan2020 to 2021Enrolled39ConditionsAutonomic Nervous System, HypertensionArmsα1-adrenergic block, Placebo
NCT06502535 nacompletednot on this mapstarted 2023, after this paper: background citation

The Effects of Inulin and Inorganic Nitrate on Flow-Mediated Dilation and Gut Microbiome in Adults with Pre-Hypertension and Hypertension

TypeinterventionalSponsorUniversity of ExeterRan2023 to 2024Enrolled22ConditionsEndothelial Dysfunction, High Blood Pressure, Gut Microbiota Dysbiosis and NutritionArmsInulin, Potassium nitrate and inulin
3 · Its place in the literature

Who cites it

359 citing papers in PubMed, 36 syntheses or guidelines pooled it.

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299 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yoichi InabaDivision of Cardiovascular Medicine, Oregon Health and Science University, UHN62, Portland, OR 97239, USA. yoichiinaba@yahoo.com
Jennifer A Chen
Steven R Bergmann

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe conducted a meta-analysis of observational studies which examined the association between flow-mediated dilatation (FMD) of brachial artery, a noninvasive measure of endothelial function, and future cardiovascular events.

methodsElectronic databases were searched using a predefined search strategy. Data was independently abstracted on study characteristics, study quality, and outcomes by two reviewers. The multivariate relative risks, adjusted for confounding factors, were calculated from individual studies and then pooled using random-effects models. Statistical heterogeneity was evaluated using I2 statistics. Subgroup analyses and meta-regression analyses were conducted to assess the robustness of the meta-analysis. Publication bias was examined with funnel plot analysis and Egger's test.

resultsFour population-based cohort studies and ten convenience-cohort studies, involving 5,547 participants, were included in the meta-analysis. The pooled relative risks of cardiovascular events per 1% increase in brachial FMD, adjusted for confounding risk factors, was 0.87 (95% CI, 0.83- 0.91). The significant associations between brachial FMD and cardiovascular events were consistent among all subgroups evaluated, suggesting the robustness of the meta-analysis. However, the presence of heterogeneity in study quality, the remaining confounding factors, and publication bias in the available literature prevent a definitive evaluation of the additional predictive value of brachial FMD beyond traditional cardiovascular risk factors.

conclusionsThe meta-analysis of heterogeneous studies with moderate methodological quality suggested that impairment of brachial FMD is significantly associated with future cardiovascular events. Further prospective randomized trials are warranted to confirm the efficacy of the usage of brachial FMD in the management of cardiovascular diseases.

Indexed as

Diagnostic Techniques, CardiovascularVasodilationAgedBrachial ArteryCardiovascular DiseasesHumansMiddle AgedPredictive Value of TestsPrognosisRegional Blood FlowRisk AssessmentRisk FactorsVascular Diseases

Identifiers

PMID20339920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.