ArticlePloS one2010
The dopamine transporter gene, a spectrum of most common risky behaviors, and the legal status of the behaviors.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- A Systematic Review of the Balloon Analogue Risk Task (BART) in Alcohol Research.Alcohol and alcoholism (Oxford, Oxfordshire) · 2022Pooled it
- Pharmacogenetic role of dopamine transporter (SLC6A3) variation on response to disulfiram treatment for cocaine addiction.The American journal on addictions · 2019Trial
- Association of the SLC6A3 Gene rs2652511 Polymorphism with Methamphetamine Abuse Disorder in the Iranian Population.Addiction & health · 2025Article
- Prominent genetic variants and epigenetic changes in post-traumatic stress disorder among combat veterans.Molecular biology reports · 2024Review
- Association of Dopamine Transporter Gene (DAT1) 40 bp 3' UTR VNTR Polymorphism (rs28363170) and Cannabis Use Disorder.Substance abuse : research and treatment · 2023Article
- FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors.Journal of personalized medicine · 2022Article
- Cohort Profile: The National Longitudinal Study of Adolescent to Adult Health (Add Health).International journal of epidemiology · 2019Article
- Genetic and Environmental Risk Factors for Cannabis Use: Preliminary Results for the Role of Parental Care Perception.Substance use & misuse · 2019Article
- The Impact of Childhood Obesity on Health and Health Service Use.Health services research · 2018Article
- Activation of RHO-1 in cholinergic motor neurons competes with dopamine signalling to control locomotion.PloS one · 2018Article
- A genetic marker of risk in HIV-infected individuals with a history of hazardous drinking.AIDS care · 2017Observational
- Waist circumference, body mass index, and employment outcomes.The European journal of health economics : HEPAC : health economics in prevention and care · 2017Article
- Transactional Links Between Teacher-Student Relationships and Adolescent Rule-Breaking Behavior and Behavioral School Engagement: Moderating Role of a Dopaminergic Genetic Profile Score.Journal of youth and adolescence · 2016Article
- Socio-Genomics and Structural Competency.Journal of bioethical inquiry · 2016Article
- Genes in the dopaminergic system and delinquent behaviors across the life course: the role of social controls and risks.Criminal justice and behavior · 2014Article
- Social, behavioral, and genetic linkages from adolescence into adulthood.American journal of public health · 2013Article
- The challenge of causal inference in gene-environment interaction research: leveraging research designs from the social sciences.American journal of public health · 2013Article
- Genetic sensitivity to peer behaviors: 5HTTLPR, smoking, and alcohol consumption.Journal of health and social behavior · 2013Article
- The National Longitudinal Study of Adolescent Health (Add Health) sibling pairs data.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2013Article
- DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART).PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
This study tests the specific hypothesis that the 9R/9R genotype in the VNTR of the dopamine transporter gene (DAT1) exerts a general protective effect against a spectrum of risky behaviors in comparison to the 10R/9R and 10R/10R genotypes, drawing on three-time repeated measures of risky behaviors in adolescence and young adulthood on about 822 non-Hispanic white males from the Add Health study. Our data have established two empirical findings. The first is a protective main effect in the DAT1 gene against risky behaviors. The second finding is that the protective effect varies over age, with the effect prominent at ages when a behavior is illegal and the effect largely vanished at ages when the behavior becomes legal or more socially tolerated. Both the protective main effect and the gene-lifecourse interaction effect are replicated across a spectrum of most common risky behaviors: delinquency, variety of sexual partners, binge drinking, drinking quantity, smoking quantity, smoking frequency, marijuana use, cocaine use, other illegal drug use, and seatbelt non-wearing. We also compared individuals with the protective genotype and individuals without it in terms of age, physical maturity, verbal IQ, GPA, received popularity, sent popularity, church attendance, two biological parents, and parental education. These comparisons indicate that the protective effect of DAT1*9R/9R cannot be explained away by these background characteristics. Our work demonstrates how legal/social contexts can enhance or reduce a genetic effect on risky behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.