ArticleInternational journal of molecular sciences2009
The role of bloom index of gelatin on the interaction with retinal pigment epithelial cells.
Article in International journal of molecular sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- Functional scaffolds design strategies for retinal repair and regeneration.Materials today. Bio · 2025Review
- Improving Atorvastatin Release from Polyelectrolyte Complex-Based Hydrogels Using Freeze-Drying: Formulation and Pharmaceutical Assessment of a Novel Delivery System for Oral Candidiasis Treatment.International journal of molecular sciences · 2025Article
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- Gelatin as It Is: History and Modernity.International journal of molecular sciences · 2023Review
- Two Hawks with One Arrow: A Review on Bifunctional Scaffolds for Photothermal Therapy and Bone Regeneration.Nanomaterials (Basel, Switzerland) · 2023Review
- Characteristics and efficacy of fish-derived gelatin microparticles as an embolic agent in a rabbit renal model: regulation of the degradation period by molecular weight.Diagnostic and interventional radiology (Ankara, Turkey) · 2022Article
- Article
- Modified Fish Gelatin as an Alternative to Mammalian Gelatin in Modern Food Technologies.Polymers · 2020Review
- Biotechnological Preparation of Gelatines from Chicken Feet.Polymers · 2019Article
- Epigallocatechin Gallate-Loaded Gelatin-g-Poly(N-Isopropylacrylamide) as a New Ophthalmic Pharmaceutical Formulation for Topical Use in the Treatment of Dry Eye Syndrome.Scientific reports · 2017Article
- Gelatin-Based Materials in Ocular Tissue Engineering.Materials (Basel, Switzerland) · 2014Review
- Human RPE stem cells grown into polarized RPE monolayers on a polyester matrix are maintained after grafting into rabbit subretinal space.Stem cell reports · 2014Article
- Stabilization of collagen nanofibers with L-lysine improves the ability of carbodiimide cross-linked amniotic membranes to preserve limbal epithelial progenitor cells.International journal of nanomedicine · 2014Article
- Influence of solvent composition on the performance of carbodiimide cross-linked gelatin carriers for retinal sheet delivery.Journal of materials science. Materials in medicine · 2013Article
- Corneal stromal cell growth on gelatin/chondroitin sulfate scaffolds modified at different NHS/EDC molar ratios.International journal of molecular sciences · 2013Article
- Biodegradable in situ gelling delivery systems containing pilocarpine as new antiglaucoma formulations: effect of a mercaptoacetic acid/N-isopropylacrylamide molar ratio.Drug design, development and therapy · 2013Article
- Article
- Biocompatibility of genipin and glutaraldehyde cross-linked chitosan materials in the anterior chamber of the eye.International journal of molecular sciences · 2012Article
- Nanoscale modification of porous gelatin scaffolds with chondroitin sulfate for corneal stromal tissue engineering.International journal of nanomedicine · 2012Article
- Biocompatibility of chemically cross-linked gelatin hydrogels for ophthalmic use.Journal of materials science. Materials in medicine · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biocompatible materials are of considerable interest in the development of cell/drug delivery carriers for therapeutic applications. This paper investigates the effects of the Bloom index of gelatin on its interaction with retinal pigment epithelial (RPE) cells. Following two days of culture of ARPE-19 cells with gelatin samples G75-100, G175, and G300, the in vitro biocompatibility was determined by cell proliferation and viability assays, and glutamate uptake measurements, as well as cytokine expression analyses. The mitochondrial dehydrogenase activity in the G300 groups was significantly lower than that of G75-100 and G175 groups. The Live/Dead assays also showed that the gelatin samples G300 induced mild cytotoxicity. In comparison with the treatment of gelatins with low Bloom index, the exposure to high Bloom strength gelatins markedly reduced the glutamate uptake capacity of ARPE-19 cells. One possible explanation for these observations is that the presence of gelatin samples G300 with high viscosity in the medium may affect the nutrient availability to cultured cells. The analyses of pro-inflammatory cytokine IL-6 expression at both mRNA and protein levels showed that the gelatins with low Bloom index caused less cellular inflammatory reaction and had more acceptable biocompatibility than their high Bloom strength counterparts. These findings suggest that the Bloom index gives influence on cellular responses to gelatin materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.