ReviewHepatology (Baltimore, Md.)2009
Advances in pediatric nonalcoholic fatty liver disease.
Review in Hepatology (Baltimore, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02116192 (Early Intervention and Prevention of Non-Alcoholic Fatty Liver Disease in Adolescents), which is not on this map. Cited by 107 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Intervention and Prevention of Non-Alcoholic Fatty Liver Disease in Adolescents
Who cites it
107 citing papers in PubMed, 3 syntheses or guidelines pooled it, 263 citations in OpenAlex.
- KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease.Clinical and molecular hepatology · 2021Guideline
- Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.Journal of gastroenterology · 2015Guideline
- KASL clinical practice guidelines: management of nonalcoholic fatty liver disease.Clinical and molecular hepatology · 2013Guideline
- Trial
- Inter-examination precision of magnitude-based MRI for estimation of segmental hepatic proton density fat fraction in obese subjects.Journal of magnetic resonance imaging : JMRI · 2014Trial
- A low-glycemic-load versus low-fat diet in the treatment of fatty liver in obese children.Childhood obesity (Print) · 2013Trial
- Influence of elevated liver fat on circulating adipocytokines and insulin resistance in obese Hispanic adolescents.Pediatric obesity · 2012Trial
- Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial.JAMA · 2011 · on this mapTrial
- Normal liver stiffness values measured with MR elastography and two-dimensional shear wave elastography in children aged 9-17 years.Abdominal radiology (New York) · 2026Article
- Metabolic dysfunction-associated steatotic liver disease-a review of the cardiometabolic perspectives and treatments in children.International journal of obesity (2005) · 2026Review
- Metabolic features in plasma and urine of obese children and their association with MAFLD risk.Frontiers in nutrition · 2026Article
- Diagnosis and Management of Pediatric Non-Alcoholic Fatty Liver Disease: An Overview.Metabolites · 2025Review
- Should Bariatric Surgery Play a Larger Role in the Management of Pediatric Patients with Severe Obesity and End-Stage Organ Disease?Obesity surgery · 2023Article
- Prevalence of non-alcoholic fatty liver disease in overweight and obese children seeking ambulatory healthcare in Nairobi, Kenya.BMJ open gastroenterology · 2023Article
- Effects of Different Vegetable Oils on the Nonalcoholic Fatty Liver Disease in C57/BL Mice.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Dietary fat composition shapes bile acid metabolism and severity of liver injury in a pig model of pediatric NAFLD.American journal of physiology. Endocrinology and metabolism · 2022Article
- Nonalcoholic fatty liver disease in children with obesity- observations from one clinical centre in the Western Pomerania region.Frontiers in endocrinology · 2022Article
- Gestational exposure to high fat diets and bisphenol A alters metabolic outcomes in dams and offspring, but produces hepatic steatosis only in dams.Chemosphere · 2022Article
- Impact of Weight Reduction on Thyroid Function and Nonalcoholic Fatty Liver among Egyptian Adolescents with Obesity.International journal of endocrinology · 2022Article
- The role of oxidized lipid species in insulin resistance and NASH in children.Frontiers in endocrinology · 2022Review
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledNonalcoholic fatty liver disease (NAFLD) has emerged as the leading cause of chronic liver disease in children and adolescents in the United States. A two- to three-fold rise in the rates of obesity and overweight in children over the last two decades is probably responsible for the NAFLD epidemic. Emerging data suggest that children with nonalcoholic steatohepatitis (NASH) progress to cirrhosis, which may ultimately increase liver-related mortality. More worrisome is the recognition that cardiovascular risk and morbidity in children and adolescents are associated with fatty liver. Pediatric fatty liver disease often displays a histologic pattern distinct from that found in adults. Liver biopsy remains the gold standard for diagnosis of NASH. Noninvasive biomarkers are needed to identify individuals with progressive liver injury. Targeted therapies to improve liver histology and metabolic abnormalities associated with fatty liver are needed. Currently, randomized-controlled trials are underway in the pediatric population to define pharmacologic therapy for NAFLD.
conclusionPublic health awareness and intervention are needed to promote healthy diet, exercise, and lifestyle modifications to prevent and reduce the burden of disease in the community.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.