ArticleThe American journal of clinical nutrition2009
Taste receptors for umami: the case for multiple receptors.
Article in The American journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 209 citations in OpenAlex.
- Molecular and Computational Basis of Taste Perception: A Review toward the "Digital Language of Taste".ACS omega · 2026Review
- Changes in non-volatile taste components and aroma profiles of giant freshwater prawn (Food chemistry: X · 2025Article
- Unexpected loss of TAS1R1-TAS1R3 umami taste receptor function in carnivorous Lyncodontini mustelids.Chemical senses · 2025Article
- Amino acids activate parallel chemosensory pathways in Drosophila.Chemical senses · 2025Article
- Effects of purine and pyrimidine 5'-ribonucleotides on glutamate detection threshold and umami intensity in Japanese young female trained participants.Chemical senses · 2025Article
- Bitter taste receptors as sensors of gut luminal contents.Nature reviews. Gastroenterology & hepatology · 2025Review
- Research advances in mushroom umami: substance characteristics, multidimensional attributes, umami peptide screening, and umami assessment.Current research in food science · 2025Review
- Mini review of plant products as food supplement against MSG-induced liver injury: antioxidant, oxidative stress and histological prospects.Frontiers in pharmacology · 2025Review
- Comparison of Nutritional Flavor Substances in Meat Between Shanghai Local Pig Breeds and Commercial DLY Breed.Foods (Basel, Switzerland) · 2024Article
- Enhancing the Quality of Ready-to-Eat Trout Burger Patties: Investigating the Combination of Modified Atmosphere Packaging and Microbial Transglutaminase Enzyme.Food science & nutrition · 2024Article
- Isolation and Identification of Novel Taste-ModulatingJournal of agricultural and food chemistry · 2024Article
- Tastant-receptor interactions: insights from the fruit fly.Frontiers in nutrition · 2024Review
- Ribonucleotides differentially modulate oral glutamate detection thresholds.Chemical senses · 2024Article
- Heterodimerization of Chemoreceptors TAS1R3 and mGluInternational journal of molecular sciences · 2023Article
- Role of Taste Receptors in Innate Immunity and Oral Health.Journal of dental research · 2022Review
- Disrupted long-range gene regulations elucidate shared tissue-specific mechanisms of neuropsychiatric disorders.Molecular psychiatry · 2022Article
- Molecular insights into human taste perception and umami tastants: A review.Journal of food science · 2022Review
- Pharmacology of the Umami Taste Receptor.Handbook of experimental pharmacology · 2022Article
- The attractive effects of amino acids and some classical substances on grass carp (Ctenopharyngodon idellus).Fish physiology and biochemistry · 2021Article
- Understanding the evolution of nutritive taste in animals: Insights from biological stoichiometry and nutritional geometry.Ecology and evolution · 2021Review
6 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Umami taste is elicited by many small molecules, including amino acids (glutamate and aspartate) and nucleotides (monophosphates of inosinate or guanylate, inosine 5'-monophosphate and guanosine-5'-monophosphate). Mammalian taste buds respond to these diverse compounds via membrane receptors that bind the umami tastants. Over the past 15 y, several receptors have been proposed to underlie umami detection in taste buds. These receptors include 2 glutamate-selective G protein-coupled receptors, mGluR4 and mGluR1, and the taste bud-expressed heterodimer T1R1+T1R3. Each of these receptors is expressed in small numbers of cells in anterior and posterior taste buds. The mGluRs are activated by glutamate and certain analogs but are not reported to be sensitive to nucleotides. In contrast, T1R1+T1R3 is activated by a broad range of amino acids and displays a strongly potentiated response in the presence of nucleotides. Mice in which the Grm4 gene is knocked out show a greatly enhanced preference for umami tastants. Loss of the Tas1r1 or Tas1R3 genes is reported to depress but not eliminate neural and behavioral responses to umami. When intact mammalian taste buds are apically stimulated with umami tastants, their functional responses to umami tastants do not fully resemble the responses of a single proposed umami receptor. Furthermore, the responses to umami tastants persist in the taste cells of T1R3-knockout mice. Thus, umami taste detection may involve multiple receptors expressed in different subsets of taste cells. This receptor diversity may underlie the complex perception of umami, with different mixtures of amino acids, peptides, and nucleotides yielding subtly distinct taste qualities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.