Evidence map›Paper›PMID 18762476›Full record

Trial reportBMJ (Clinical research ed.)2008

Low dose aspirin and cognitive function in middle aged to elderly adults: randomised controlled trial.

Jackie F Price, Marlene C Stewart, Ian J Deary, Gordon D Murray, Peter Sandercock, Isabella Butcher, F Gerald R Fowkes, AAA Trialists

Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 5 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Pooled it
  5. Aspirin for vascular dementia.The Cochrane database of systematic reviews · 2000
    Pooled it
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  8. Trial
  9. Inter-arm blood pressure difference and mortality: a cohort study in an asymptomatic primary care population at elevated cardiovascular risk.The British journal of general practice : the journal of the Royal College of General Practitioners · 2016
    Trial
  10. Trial
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Impact of age and cyclooxygenase inhibition on the hemodynamic response to acute cognitive challenges.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Jackie F PriceDivision of Community Health Sciences and Centre for Public Health and Primary Care Research, University of Edinburgh, Edinburgh. Jackie.Price@ed.ac.uk
Marlene C Stewart
Ian J Deary
Gordon D Murray
Peter Sandercock
Isabella Butcher
F Gerald R Fowkes
AAA Trialists
University of Edinburgh · GB

Funding

British Heart FoundationChief Scientist OfficeWellcome Trust
6 · The paper itself

Abstract

objectiveTo determine the effects of low dose aspirin on cognitive function in middle aged to elderly men and women at moderately increased cardiovascular risk.

designRandomised double blind placebo controlled trial.

settingCentral Scotland.

participants3350 men and women aged over 50 participating in the aspirin for asymptomatic atherosclerosis trial.

interventionLow dose aspirin (100 mg daily) or placebo for five years.

main outcome measuresTests of memory, executive function, non-verbal reasoning, mental flexibility, and information processing five years after randomisation, with scores used to create a summary cognitive score (general factor).

resultsAt baseline, mean vocabulary scores (an indicator of previous cognitive ability) were similar in the aspirin (30.9, SD 4.7) and placebo (31.1, SD 4.7) groups. In the primary intention to treat analysis, there was no significant difference at follow-up between the groups in the proportion achieving over the median general factor cognitive score (32.7% and 34.8% respectively, odds ratio 0.91, 95% confidence interval 0.79 to 1.05, P=0.20) or in mean scores on the individual cognitive tests. There were also no significant differences in change in cognitive ability over the five years in a subset of 504 who underwent detailed cognitive testing at baseline.

conclusionLow dose aspirin does not affect cognitive function in middle aged to elderly people at increased cardiovascular risk.

trial registrationISRCTN 66587262.

Indexed as

AgedAspirinAtherosclerosisCognition DisordersDouble-Blind MethodDrug Administration ScheduleFemaleHumansMaleMiddle AgedNeuroprotective AgentsNeuropsychological TestsPatient ComplianceAspirinNeuroprotective Agents

Identifiers

PMID18762476
PMCPMC2527654
OpenAlexW2105787422

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.