ArticleApplied and environmental microbiology2008
Antibacterial activities of naturally occurring compounds against Mycobacterium avium subsp. paratuberculosis.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- The role of natural products in treatment of non-tuberculous mycobacterial infections: a systematic review.Antonie van Leeuwenhoek · 2026Pooled it
- Exploring the Inhibitory Effects of Some Detergents onACS omega · 2026Article
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- FermentedNutrients · 2025Article
- Evaluation of the cytotoxicity and antibacterial activity of a synthetic tunicamycin derivative againstFrontiers in microbiology · 2025Article
- Use of Essential Oils to Counteract the Phenomena of Antimicrobial Resistance in Livestock Species.Antibiotics (Basel, Switzerland) · 2024Review
- Rapid-killing efficacy substantiates the antiseptic property of the synergistic combination of carvacrol and nerol against nosocomial pathogens.Archives of microbiology · 2022Article
- Identification of Mycobacterium avium subspecies paratuberculosis in sheep farms in Bayannaoer, Inner Mongolia, China (short communication).BMC veterinary research · 2022Article
- Review
- Mint Oils: In Vitro Ability to Perform Anti-Inflammatory, Antioxidant, and Antimicrobial Activities and to Enhance Intestinal Barrier Integrity.Antioxidants (Basel, Switzerland) · 2021Article
- Article
- Use of Essential Oils in Veterinary Medicine to Combat Bacterial and Fungal Infections.Veterinary sciences · 2020Review
- Imine-Based Catechols andACS omega · 2020Article
- Efficacy of carvacrol against resistant rapidly growing mycobacteria in the planktonic and biofilm growth mode.PloS one · 2019Article
- Nutritional Intervention for the Intestinal Development and Health of Weaned Pigs.Frontiers in veterinary science · 2019Review
- Phytochemicals as antibiotic alternatives to promote growth and enhance host health.Veterinary research · 2018Review
- Non-antibiotic feed additives in diets for pigs: A review.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2018Review
- Antibacterial and Antitubercular Activities of Cinnamylideneacetophenones.Molecules (Basel, Switzerland) · 2017Article
- Mechanisms of Antimicrobial Action of Cinnamon and Oregano Oils, Cinnamaldehyde, Carvacrol, 2,5-Dihydroxybenzaldehyde, and 2-Hydroxy-5-Methoxybenzaldehyde against Mycobacterium avium subsp. paratuberculosis (Map).Foods (Basel, Switzerland) · 2017Article
- Effect of structure on the interactions between five natural antimicrobial compounds and phospholipids of bacterial cell membrane on model monolayers.Molecules (Basel, Switzerland) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The antibacterial activities of 18 naturally occurring compounds (including essential oils and some of their isolated constituents, apple and green tea polyphenols, and other plant extracts) against three strains of Mycobacterium avium subsp. paratuberculosis (a bovine isolate [NCTC 8578], a raw-milk isolate [806R], and a human isolate [ATCC 43015]) were evaluated using a macrobroth susceptibility testing method. M. avium subsp. paratuberculosis was grown in 4 ml Middlebrook 7H9 broth containing 10% oleic acid-albumin-dextrose-catalase, 0.05% Tween 80 (or 0.2% glycerol), and 2 microg/ml mycobactin J supplemented with five concentrations of each test compound. The changes in the optical densities of the cultures at 600 nm as a measure of CFU were recorded at intervals over an incubation period of 42 days at 37 degrees C. Six of the compounds were found to inhibit the growth of M. avium subsp. paratuberculosis. The most effective compound was trans-cinnamaldehyde, with a MIC of 25.9 microg/ml, followed by cinnamon oil (26.2 microg/ml), oregano oil (68.2 microg/ml), carvacrol (72.2 microg/ml), 2,5-dihydroxybenzaldehyde (74 microg/ml), and 2-hydroxy-5-methoxybenzaldehyde (90.4 microg/ml). With the exception of carvacrol, a phenolic compound, three of the four most active compounds are aldehydes, suggesting that the structure of the phenolic group or the aldehyde group may be important to the antibacterial activity. No difference in compound activity was observed between the three M. avium subsp. paratuberculosis strains studied. Possible mechanisms of the antimicrobial effects are discussed.
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Registered trials
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