ArticleJournal of general internal medicine2008
Prevalence of musculoskeletal pain and statin use.
Article in Journal of general internal medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- Evaluating the Association Between Low-Density Lipoprotein Cholesterol Reduction and Relative and Absolute Effects of Statin Treatment: A Systematic Review and Meta-analysis.JAMA internal medicine · 2022 · on this mapPooled it
- Impact of SLCO1B1 Pharmacogenetic Testing on Patient and Healthcare Outcomes: A Systematic Review.Clinical pharmacology and therapeutics · 2019Pooled it
- Baseline Characteristics of Participants in STAREE: A Randomized Trial for Primary Prevention of Cardiovascular Disease Events and Prolongation of Disability-Free Survival in Older People.Journal of the American Heart Association · 2024Trial
- Low vitamin D does not predict statin associated muscle symptoms but is associated with transient increases in muscle damage and pain.Atherosclerosis · 2017Trial
- Factors Associated with Chronic Low Back Pain in Hungary Based on the European Health Interview Surveys Conducted in 2009, 2014, and 2019: A Repeated Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Prevalence of substances with OATP1B1 inhibitory properties in individual case safety reports of suspected statin-associated myopathy - an analysis of Swiss pharmacovigilance data.European journal of clinical pharmacology · 2026Article
- Uncovering the Relationship Between Statins and Muscle Problems in the ELSA-Brasil MSK Cohort.Cardiovascular drugs and therapy · 2024Article
- Statins affect human iPSC-derived cardiomyocytes by interfering with mitochondrial function and intracellular acidification.Basic research in cardiology · 2024Article
- Statins and Cardiomyocyte Metabolism, Friend or Foe?Journal of cardiovascular development and disease · 2023Review
- Are doctors using more preventive medication for cardiovascular disease? A Swedish cross-sectional study.Scandinavian journal of primary health care · 2023Article
- Mitochondrial complex III activity: from invasive muscle biopsies to patient-friendly buccal swab analysis.Scientific reports · 2023Article
- Article
- Translating questions to estimands in randomized clinical trials with intercurrent events.Statistics in medicine · 2022Article
- [Rare diseases in the differential diagnosis of myalgia].Schmerz (Berlin, Germany) · 2022Article
- Refractory Statin-Induced Immune-Mediated Necrotizing Myositis: Challenges and Perils in Its Management.Cureus · 2022Article
- Lipid-Targeted Atherosclerotic Risk Reduction in Older Adults: A Review.Geriatrics (Basel, Switzerland) · 2022Review
- Regression discontinuity analysis for pharmacovigilance: statin example reflected trial findings showing little evidence of harm.Journal of clinical epidemiology · 2022Article
- Bempedoic Acid in the Treatment of Patients with Dyslipidemias and Statin Intolerance.Cardiovascular drugs and therapy · 2021Review
- Statin Treatment in Specific Patient Groups: Role for Improved Cardiovascular Risk Markers.Journal of clinical medicine · 2020Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMuscle effects are the most common reported adverse effects of 3-hydroxy-3-methylglutaryl coenzyme A inhibitors (statins). However, in placebo-controlled trials the incidence of muscle pain is most often similar for placebo and active control groups.
objectiveWe sought to evaluate whether statin use was associated with a higher prevalence of musculoskeletal pain in a nationally representative sample.
methodsCross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. Participants were 3,580 adults > or =40 years without arthritis who were interviewed at home and examined in a mobile examination center. Participants were asked about sociodemographic characteristics, health conditions, medication use, and musculoskeletal pain. Height, weight, blood pressure, ankle brachial index, and cholesterol were measured. MEASUREMENTS AND MAIN
resultsPrevalence and adjusted odds ratios (OR) of any musculoskeletal pain and musculoskeletal pain in 4 different anatomical regions (neck/upper back, upper extremities, lower back, and lower extremities) by statin use during the last 30 days. Among statin users (n = 402), 22.0% (95%CI 18.0-26.7%) reported musculoskeletal pain in at least 1 anatomical region during the last 30 days, compared with 16.7% (95%CI 15.1-18.4%) of those who did not use a statin. Compared to persons who did not use statins, those who used statins had multivariable-adjusted odds ratios (95%CI; p value) of 1.50 (1.07-2.11; p = .01) for any musculoskeletal pain, 1.59 (1.04-2.44, p = .03) for lower back pain, and 1.50 (1.02-2.22, p = .03) for lower extremity pain.
conclusionMusculoskeletal pain is common in adults > or =40 years without arthritis. In this nationally representative sample, statin users were significantly more likely to report musculoskeletal pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.