ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Umami responses in mouse taste cells indicate more than one receptor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 142 citations in OpenAlex.
- UmamiPredict: machine learning model to predict umami taste of molecules and peptides.Molecular diversity · 2026Article
- Noncanonical Taste Transduction of Sugars Elicits Responses in a Dedicated Subset of Gustatory Afferent Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Conditioned Taste Aversion to L-Amino Acid Taste Stimuli and Oral Transcriptional Changes to Type 1 Taste Receptors T1R1 and T1R3 on Chronic Exposure to L-Alanine Solution in Chickens.The journal of poultry science · 2022Article
- Fine-tuning of epithelial taste bud organoid to promote functional recapitulation of taste reactivity.Cellular and molecular life sciences : CMLS · 2022Article
- Taste Receptor Signaling.Handbook of experimental pharmacology · 2022Article
- Protein Appetite at the Interface between Nutrient Sensing and Physiological Homeostasis.Nutrients · 2021Review
- A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli.PLoS genetics · 2020Article
- Sensing Senses: Optical Biosensors to Study Gustation.Sensors (Basel, Switzerland) · 2020Review
- Review
- Amino acid sensing in hypothalamic tanycytes via umami taste receptors.Molecular metabolism · 2017Article
- Article
- Article
- Genetics of Amino Acid Taste and Appetite.Advances in nutrition (Bethesda, Md.) · 2016Review
- The Effect of Temperature on Umami Taste.Chemical senses · 2016Article
- Mice perceive synergistic umami mixtures as tasting sweet.Chemical senses · 2015Article
- Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice.The Journal of physiology · 2015Article
- L-Amino Acids Elicit Diverse Response Patterns in Taste Sensory Cells: A Role for Multiple Receptors.PloS one · 2015Article
- Review
- Gustatory sensory cells express a receptor responsive to protein breakdown products (GPR92).Histochemistry and cell biology · 2013Article
- Taste responses in mice lacking taste receptor subunit T1R1.The Journal of physiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
A number of gustatory receptors have been proposed to underlie umami, the taste of L-glutamate, and certain other amino acids and nucleotides. However, the response profiles of these cloned receptors have not been validated against responses recorded from taste receptor cells that are the native detectors of umami taste. We investigated umami taste responses in mouse circumvallate taste buds in an intact slice preparation, using confocal calcium imaging. Approximately 5% of taste cells selectively responded to L-glutamate when it was focally applied to the apical chemosensitive tips of receptor cells. The concentration-response range for L-glutamate fell approximately within the physiologically relevant range for taste behavior in mice, namely 10 mm and above. Inosine monophosphate enhanced taste cell responses to L-glutamate, a characteristic feature of umami taste. Using pharmacological agents, ion substitution, and immunostaining, we showed that intracellular pathways downstream of receptor activation involve phospholipase C beta2. Each of the above features matches those predicted by studies of cloned and expressed receptors. However, the ligand specificity of each of the proposed umami receptors [taste metabotropic glutamate receptor 4, truncated metabotropic glutamate receptor 1, or taste receptor 1 (T1R1) and T1R3 dimers], taken alone, did not appear to explain the taste responses observed in mouse taste cells. Furthermore, umami responses were still observed in mutant mice lacking T1R3. A full explanation of umami taste transduction may involve novel combinations of the proposed receptors and/or as-yet-undiscovered taste receptors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.