Trial reportDiabetes care2006
Lifestyle intervention is associated with lower prevalence of urinary incontinence: the Diabetes Prevention Program.
Trial report in Diabetes care, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 152 citations in OpenAlex.
- Evidence of the Impact of Diet, Fluid Intake, Caffeine, Alcohol and Tobacco on Lower Urinary Tract Symptoms: A Systematic Review.The Journal of urology · 2017Pooled it
- Lifestyle interventions for the treatment of urinary incontinence in adults.The Cochrane database of systematic reviews · 2015Pooled it
- Sex-specific differences in diabetes prevention: a systematic review and meta-analysis.Diabetologia · 2015 · on this mapPooled it
- Obesity and pelvic floor disorders: a systematic review.Obstetrics and gynecology · 2008Pooled it
- Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study.The lancet. Diabetes & endocrinology · 2015 · on this mapTrial
- Long-term prevalence and predictors of urinary incontinence among women in the Diabetes Prevention Program Outcomes Study.International journal of urology : official journal of the Japanese Urological Association · 2015 · on this mapTrial
- Weight loss prevents urinary incontinence in women with type 2 diabetes: results from the Look AHEAD trial.The Journal of urology · 2012Trial
- Weight loss improves fecal incontinence severity in overweight and obese women with urinary incontinence.International urogynecology journal · 2011Trial
- Fecal incontinence in obese women with urinary incontinence: prevalence and role of dietary fiber intake.American journal of obstetrics and gynecology · 2009Trial
- Effects of Nonpharmacological and Nonsurgical Intervention for Lower Urinary Tract Symptoms in Parkinson's Disease: A Systematic Review and Meta-analysis.European urology open science · 2026Review
- Article
- Association between obesity and urinary incontinence in older adults from multiple nationwide longitudinal cohorts.Communications medicine · 2023Article
- Prevalence of Stress Urinary Incontinence and Risk Factors among Saudi Females.Medicina (Kaunas, Lithuania) · 2023Article
- Article
- Urologic complications in diabetes.Journal of diabetes and its complications · 2022Review
- Longitudinal patterns of urinary incontinence and associated predictors in women with type 1 diabetes.Neurourology and urodynamics · 2022Article
- Urodynamic and questionnaire findings in urinary incontinent women with and without diabetes. Data from a health study.International urogynecology journal · 2021Article
- Epidemiological survey of adult female stress urinary incontinence.BMC women's health · 2021Article
- Acupuncture for diabetic neurogenic bladder: A protocol for systematic review and meta-analysis.Medicine · 2021Article
- Prevention of Urinary Incontinence in Women.Current urology reports · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveDiabetes is associated with increased urinary incontinence risk. Weight loss improves incontinence, but exercise may worsen this condition. We examined whether an intensive lifestyle intervention or metformin therapy among overweight pre-diabetic women was associated with a lower prevalence of incontinence. RESEARCH DESIGN AND
methodsWe analyzed data from the Diabetes Prevention Program, a randomized controlled trial in 27 U.S. centers. Of the 1,957 women included in this analysis, 660 (34%) were randomized to intensive lifestyle therapy, 636 (32%) to metformin, and 661 (34%) to placebo with standard lifestyle advice. The main outcome measure was incontinence symptoms by frequency and type by a validated questionnaire completed at the end-of-trial visit (mean 2.9 years).
resultsThe prevalence of total (stress or urge) weekly incontinence was lower among women in the intensive lifestyle group (38.3%) than those randomized to metformin (48.1%) or placebo (45.7%). This difference was most apparent among women with stress incontinence (31.3% for intensive lifestyle group vs. 39.7% for metformin vs. 36.7% for placebo, P = 0.006). Changes in weight accounted for most of the protective effect of the intensive lifestyle intervention on stress incontinence.
conclusionsLess-frequent urinary incontinence may be a powerful motivator for women to choose lifestyle modification to prevent diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.