← Statins × cardiovascular events

TrialJAMA2005

High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial.

Terje R Pedersen et al.PubMed ↗Publisher ↗

The primary results report of NCT00159835.

What the trial testedas reported · 8,888 people · 2005

Range includes no effect

No clear effect on cardiovascular events

−11%−22% to +1%

9 in 100 instead of 10

Bigger than 2 in 10 for cardiovascular events

As reported

HR 0.89, 95% CI 0.78–1.01

Not counted

Reduced cardiovascular events

−17%−29% to −2%

6 in 100 instead of 7

Bigger than 4 in 10 for cardiovascular events

As reported

HR 0.83, 95% CI 0.71–0.98

Not counted

Reduced cardiovascular events

−13%−23% to −2%

6 in 100 instead of 7

Bigger than 2 in 10 for cardiovascular events

As reported

HR 0.87, 95% CI 0.77–0.98

Not counted

Reduced cardiovascular events

−16%−24% to −9%

Bigger than 3 in 10 for cardiovascular events

As reported

HR 0.84, 95% CI 0.76–0.91

+2 more in the walkthrough ↓

Six numbers in the abstract

the abstract, start to end

… patients (9.3%) (hazard ratio [HR], 0.89; 95% CI, 0.78-1.01; P = .07).

… and 267 (6.0%) in the 2 groups (HR, 0.83; 95% CI, 0.71-0.98; P = .02), …

… 533 in the 2 groups, respectively (HR, 0.87; 95% CI, 0.77-0.98; P = .02).

… and 898 atorvastatin patients (HR, 0.84; 95% CI, 0.76-0.91; P<.001).

… and 143 (3.2%) in the 2 groups (HR, 0.92; 95% CI, 0.73-1.15; P = .47).

… (8.2%) in the atorvastatin group (HR, 0.98; 95% CI, 0.85-1.13; P = .81).

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
HR 0.890.78–1.01
Cardiovascular events
HR 0.830.71–0.98
Cardiovascular events
HR 0.870.77–0.98
Cardiovascular events
HR 0.840.76–0.91
Cardiovascular events
HR 0.920.73–1.15
All-cause mortality
HR 0.980.85–1.13
StatinsCardiovascular eventsAll-cause mortality
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396 papers cite itlatest 60 shown

2005
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The trial

Full record →Abstract, authors, funding and every citing paper · PMID 16287954