Evidence map›Paper›PMID 15095005›Full record

ReviewCellular and molecular life sciences : CMLS2004

Where, when and how much: regulation of myelin proteolipid protein gene expression.

P A Wight, A Dobretsova

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  3. Frontiers in cellular neuroscience · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

P A WightDepartment of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, Arkansas 72205, USA. pwight@uams.edu
A Dobretsova
University of Arkansas for Medical Sciences · USUniversity of Arkansas Medical Center · US

Funding

ANTISILENCING OF PLP GENE EXPRESSION IN OLIGODENDROCYTESR01NS037821 · NINDS · UNIV OF ARKANSAS FOR MED SCIS · PI WIGHT, PATRICIA A. · 1998 to 2010
$2.0M
NINDS NIH HHS NS37821NINDS NIH HHS R01 NS037821
6 · The paper itself

Abstract

The myelin proteolipid protein (PLP) gene ( Plp) encodes the most abundant protein found in myelin from the central nervous system (CNS). Expression of the gene is regulated in a spatiotemporal manner with maximal levels of expression occurring in oligodendrocytes during the active myelination period of CNS development, although other cell types in the CNS as well as in the periphery can express the gene to a much lower degree. In oligodendrocytes, Plp gene expression is tightly regulated. Underexpression or overexpression of the gene has been shown to have adverse effects in humans and other vertebrates. In light of this strict control, this review provides an overview of the current knowledge of Plp gene regulation.

Indexed as

Gene Expression RegulationAnimalsBase SequenceHumansMolecular Sequence DataMyelin Proteolipid ProteinProtein IsoformsSequence AlignmentMyelin Proteolipid ProteinProtein Isoforms

Identifiers

PMID15095005
PMCPMC11138688
OpenAlexW2059641442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.