ReviewMolecular and cellular biochemistry2003
Does glutathione S-transferase Pi (GST-Pi) a marker protein for cancer?
Review in Molecular and cellular biochemistry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 62 citations in OpenAlex.
- The role of cytostatic in oxidative stress reactions.Frontiers in oncology · 2025Review
- Evaluation of Phenolic Content Diversity along with Antioxidant/Pro-Oxidant, Glutathione Transferase Inhibition, and Cytotoxic Potential of Selected Commonly Used Plants.Preventive nutrition and food science · 2022Article
- Effects of the consumption of polyunsaturated fatty acids on the oxidative status of adult dogs.Journal of animal science · 2018Article
- Prognostic value of an immunohistochemical signature in patients with esophageal squamous cell carcinoma undergoing radical esophagectomy.Molecular oncology · 2018Article
- Decreases in Paraoxonase-1 Activities Promote a Pro-inflammatory Effect of Lipids Peroxidation Products in Non-smoking and Smoking Patients with Acute Pancreatitis.International journal of medical sciences · 2018Article
- Protein malnutrition during fetal programming induces fatty liver in adult male offspring rats.Journal of physiology and biochemistry · 2017Article
- Purification of Glutathione S-Transferase pi from Erythrocytes and Evaluation of the Inhibitory Effect of Hypericin.The protein journal · 2015Article
- Effects of a nutrient mixture on immunohistochemical localization of cancer markers in human cervical cancer HeLa cell tumor xenografts in female nude mice.Experimental and therapeutic medicine · 2015Article
- Acquired/intratumoral mutation of KRAS during metastatic progression of colorectal carcinogenesis.Oncology letters · 2012Article
- Article
- Decreased expression of GST pi is correlated with a poor prognosis in human esophageal squamous carcinoma.BMC cancer · 2010Article
- Soy isoflavones exert differential effects on androgen responsive genes in LNCaP human prostate cancer cells.The Journal of nutrition · 2007Article
- Comparative study on glutathione transferases of rat brain and testis under the stress of phenobarbitol and beta-methylcholanthrene.Journal of Zhejiang University. Science. B · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutathione S-transferases (GSTs, EC 2.5.1.18) are multifunctional and multigene products. They are versatile enzymes and participate in the nucleophilic attack of the sulphur atom of glutathione on the electrophilic centers of various endogenous and xenobiotic compounds. Out of the five, alpha, micro, pi, sigma and theta, major classes of GSTs, GST-pi has significance in the diagnosis of cancers as it is expressed abundantly in tumor cells. This protein is a single gene product, coded by seven exons, that is having 24 kDa mass and pI value of 7.0. Four upstream elements such as two enhancers, and one of each of AP-1 site and GC box regulate pi gene. During chemical carcinogenesis because of jun/fos oncogenes (AP-1) regulatory elements, specifically GST-pi is expressed in liver. Therefore this gene product could be used as marker protein for the detection of chemical toxicity and carcinogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.