Taking simvastatin in the morning compared with in the evening: randomised controlled trial.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it.

1. Chronotherapy versus conventional statins therapy for the treatment of hyperlipidaemia.The Cochrane database of systematic reviews · 2016 · on this map
   Pooled it
2. Statins for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2013 · on this map
   Pooled it
3. Statins for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2011 · on this map
   Pooled it
4. The clinical impact of chronopharmacology on current medicine.Naunyn-Schmiedeberg's archives of pharmacology · 2025
   Review
5. Chronobiology of Cancers in the Liver and Gut.Cancers · 2024
   Review
6. Circadian neurogenetics and its implications in neurophysiology, behavior, and chronomedicine.Neuroscience and biobehavioral reviews · 2024
   Review
7. Significant impact of time-of-day variation on metformin pharmacokinetics.Diabetologia · 2023
   Article
8. Timing Is Important-Management of Metabolic Syndrome According to the Circadian Rhythm.Biomedicines · 2023
   Review
9. Reduction of High Cholesterol Levels by a Preferably Fixed-Combination Strategy as the First Step in the Treatment of Hypertensive Patients with Hypercholesterolemia and High/Very High Cardiovascular Risk: A Consensus Document by the Italian Society of Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022
   Article
10. Circadian Rhythms, Disease and Chronotherapy.Journal of biological rhythms · 2021
    Review
11. Circadian Variation in Efficacy of Medications.Clinical pharmacology and therapeutics · 2021
    Review
12. COVID-19: Sleep, Circadian Rhythms and Immunity - Repurposing Drugs and Chronotherapeutics for SARS-CoV-2.Frontiers in neuroscience · 2021
    Review
13. Chronopharmacology of simvastatin on hyperlipidaemia in high-fat diet-fed obese mice.Journal of cellular and molecular medicine · 2020
    Article
14. P-Glycoprotein Inhibition Exacerbates Paclitaxel Neurotoxicity in Neurons and Patients With Cancer.Clinical pharmacology and therapeutics · 2020
    Article
15. Chronobiological Influence Over Cardiovascular Function: The Good, the Bad, and the Ugly.Circulation research · 2020
    Review
16. Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases.Advances in experimental medicine and biology · 2020
    Review
17. Statin Dosing Instructions, Medication Adherence, and Low-Density Lipoprotein Cholesterol: a Cohort Study of Incident Statin Users.Journal of general internal medicine · 2019
    Observational
18. [Management of different cardiovascular risk factors with a combination tablet (polypill)].Herz · 2018
    Review
19. Marketed drugs used for the management of hypercholesterolemia as anticancer armament.OncoTargets and therapy · 2017
    Review
20. Timing of Administration: For Commonly-Prescribed Medicines in Australia.Pharmaceutics · 2016
    Review

Corrections and comments

• Commented on by
  Timing of simvastatin treatment: results are not strong enough to change practice.2004
• Commented on by
  Timing of simvastatin treatment: trial is not reported according to CONSORT guidelines.2004
• Commented on by
  Timing of simvastatin treatment: results are not what really matters.2004
• Commented on by
  Timing of simvastatin treatment: no matter the time of day, does UK policy reflect the evidence?2004
• Commented on by
  Timing of simvastatin treatment: what about the shift workers?2004

Authors and funding

3 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as