Evidence map›Paper›PMID 12626436›Full record

Trial reportFASEB journal : official publication of the Federation of American Societies for Experimental Biology2003

Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans.

Rebecca Starkie, Sisse Rye Ostrowski, Sune Jauffred, Mark Febbraio, Bente Klarlund Pedersen

2 registry-linked trialsAbstract readClinical TrialRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 305 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
305citing papers in PubMed, 10 pooled it
21.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04122716 phase4unknown statusstarted 2016, after this paper: background citation

Synergy Effect of the Appetite Hormone GLP-1 (LiragluTide) and Exercise on Maintenance of Weight Loss and Health After a Low Calorie Diet - the S-LiTE Randomized Trial

Ran2016Enrolled215Registered outcomes28Posted comparisons0ConditionsObesityArmsExercise, liraglutide
PMID 23186644PMID 26132939PMID 26284720PMID 28049736PMID 30052921PMID 27295427PMID 27633186PMID 25287751PMID 23812094PMID 16464906PMID 16476868PMID 16526835other papers from this trial
Open the trial in the graph
NCT03200639 nacompletednot on this mapstarted 2015, after this paper: background citation

Comparison of High Intensity Interval Body Weight Training Versus Combined Training on Body Composition, Physical Function, Metabolic Risk and Inflammation in Postmenopausal Women With and Without Gynecological Cancer

TypeinterventionalSponsorUniversidade Federal do Triangulo MineiroRan2015 to 2015Enrolled38ConditionsBreast Cancer Female, Gynecologic Cancer, Menopause, Physical ActivityArmsCombined training, High intensity interval training with body weight
3 · Its place in the literature

Who cites it

305 citing papers in PubMed, 10 syntheses or guidelines pooled it, 763 citations in OpenAlex.

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  7. Exercise for cancer cachexia in adults.The Cochrane database of systematic reviews · 2021
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  16. BetaScandinavian journal of medicine & science in sports · 2022
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245 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Rebecca StarkieDepartment of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark.
Sisse Rye Ostrowski
Sune Jauffred
Mark Febbraio
Bente Klarlund Pedersen
Copenhagen University Hospital · DKUniversity of Copenhagen · DKRigshospitalet · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During "nondamaging" exercise, skeletal muscle markedly releases interleukin (IL)-6, and it has been suggested that one biological role of this phenomenon is to inhibit the production of tumor necrosis factor (TNF)- alpha, which is known to cause pathogenesis such as insulin resistance and atherosclerosis. To test this hypothesis, we performed three experiments in which eight healthy males either rested (CON), rode a bicycle for 3 h (EX), or were infused with recombinant human IL-6 (rhIL-6) for 3 h while they rested. After 2.5 h, the volunteers received a bolus of Escherichia coli lipopolysaccharide endotoxin (0.06 ng/kg) i.v. to induce low-grade inflammation. In CON, plasma TNF-alpha increased significantly in response to endotoxin. In contrast, during EX, which resulted in elevated IL-6, and rhIL-6, the endotoxin-induced increase in TNF-alpha was totally attenuated. In conclusion, physical exercise and rhIL-6 infusion at physiological concentrations inhibit endotoxin-induced TNF-alpha production in humans. Hence, these data provide the first experimental evidence that physical activity mediates antiinflammatory activity and suggest that the mechanism include IL-6, which is produced by and released from exercising muscles.

Indexed as

Analysis of VarianceExerciseHumansInfusions, IntravenousInterleukin-6LipopolysaccharidesMalePostureRecombinant ProteinsTumor Necrosis Factor-alphaInterleukin-6LipopolysaccharidesRecombinant ProteinsTumor Necrosis Factor-alpha

Identifiers

PMID12626436
OpenAlexW2033124959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.