Evidence map›Paper›PMID 12181210›Full record

ArticleHeart (British Cardiac Society)2002

Adherence to statin treatment and readmission of patients after myocardial infarction: a six year follow up study.

L Wei, J Wang, P Thompson, S Wong, A D Struthers, T M MacDonald

3 registry-linked trialsOpen access · bronzeAbstract read

In one paragraph

Article in Heart (British Cardiac Society), 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 86 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it

0cells of the map it votes in

86citing papers in PubMed, 11 pooled it

8.4field-weighted citation impact, top 2% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01770210 completedstarted 2013, after this paper: background citation

A Multicenter, Open-label, 30-week Observational Clinical Study to Examine the Progress of Patients After Leaving the Cardiology Clinic or Unit Due to Acute Cardiovascular Event.

Ran2013Enrolled670Registered outcomes6Posted comparisons0ConditionsCardiovascular DisordersArmsPatients on atorvastatin treatment

PMID 20425272 PMID 12132975 PMID 12132976 PMID 12505111 PMID 15883224 PMID 19367148 PMID 11966668 PMID 8604188 PMID 9416884 PMID 9851392 PMID 11914253other papers from this trial

Open the trial in the graph

NCT03973931 nacompletednot on this mapstarted 2019, after this paper: background citation

Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications (The Nudge Study)

TypeinterventionalSponsorUniversity of Colorado, DenverRan2019 to 2023Enrolled9,501ConditionsCardiovascular Diseases, Adherence, Medication, Medication Adherence, Diabetes MellitusArmsNudge

NCT04458766 nacompletednot on this mapstarted 2021, after this paper: background citation

The Use of Mobile Health Technology and Behavioral Economics to Encourage Adherence to Statins in Adolescents With Familial Hypercholesterolemia

TypeinterventionalSponsorBoston Children's HospitalRan2021 to 2024Enrolled11ConditionsFamilial Hypercholesterolemia, Adherence, MedicationArmsMonetary incentives

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 11 syntheses or guidelines pooled it, 297 citations in OpenAlex.

Methods and validity indicators for measuring adherence to statins in secondary cardiovascular prevention: a systematic review.Systematic reviews · 2025
Pooled it
Association between statin use and risk of gallstone disease and cholecystectomy: a meta-analysis of 590,086 patients.PeerJ · 2023
Pooled it
Adherence with cardiovascular medications and the outcomes in patients with coronary arterial disease: "Real-world" evidence.Clinical cardiology · 2022
Pooled it
mHealth Apps Using Behavior Change Techniques to Self-report Data: Systematic Review.JMIR mHealth and uHealth · 2022
Pooled it
Prevalence of statin intolerance: a meta-analysis.European heart journal · 2022 · on this map
Pooled it
Interventions to improve adherence to lipid-lowering medication.The Cochrane database of systematic reviews · 2016
Pooled it
Impact of statin adherence on cardiovascular disease and mortality outcomes: a systematic review.British journal of clinical pharmacology · 2014
Pooled it
Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment.Pharmacogenetics and genomics · 2013 · on this map
Pooled it
Cardiovascular medication: improving adherence.BMJ clinical evidence · 2011
Pooled it
Associations between statins and COPD: a systematic review.BMC pulmonary medicine · 2009
Pooled it
Interventions to improve adherence to lipid lowering medication.The Cochrane database of systematic reviews · 2004
Pooled it
A Conversation Tool to Enhance Care for People With Type 2 Diabetes: The QBSafe Cluster Randomized Clinical Trial.JAMA network open · 2026
Trial
Description of patient questions received by clinical pharmacists in the Nudge Study.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2023
Trial
Text Message Medication Adherence Reminders Automated and Delivered at Scale Across Two Institutions: Testing the Nudge System: Pilot Study.Circulation. Cardiovascular quality and outcomes · 2021
Trial
Length of time periods in treatment effect descriptions and willingness to initiate preventive therapy: a randomised survey experiment.BMC medical informatics and decision making · 2018
Trial
Partners and Alerts in Medication Adherence: A Randomized Clinical Trial.Journal of general internal medicine · 2018 · on this map
Trial
The impact of the time of drug administration on the effectiveness of combined treatment of hypercholesterolemia with Rosuvastatin and Ezetimibe (RosEze): study protocol for a randomized controlled trial.Trials · 2017
Trial
Patient and Partner Feedback Reports to Improve Statin Medication Adherence: A Randomized Control Trial.Journal of general internal medicine · 2017
Trial
Impact of a pharmacist-delivered discharge and follow-up intervention for patients with acute coronary syndromes in Qatar: a study protocol for a randomised controlled trial.BMJ open · 2016
Trial
Effect of Financial Incentives to Physicians, Patients, or Both on Lipid Levels: A Randomized Clinical Trial.JAMA · 2015 · on this map
Trial

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

Commented on by
Patient compliance is a critical factor in the effectiveness of cardiac prevention.2003

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

L WeiMedicines Monitoring Unit, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK.

J Wang

P Thompson

S Wong

A D Struthers

T M MacDonald

Ninewells Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate patients' adherence to statin treatment prescribed following their first myocardial infarction (MI) and to estimate the effect of adherence to statins on recurrence of MI and all cause mortality.

designCohort study using a record linkage database.

settingTayside, Scotland, UK. PATIENTS: Patients who experienced their first MI between January 1990 and November 1995.

main outcome measuresPercentage of statin use and adherence to statins by patients after an MI and the relative risk of hospitalisation for recurrent MI. The effect of adherence on all cause mortality was also examined. The covariates used were age, sex, socioeconomic deprivation, serum cholesterol concentration, diabetes mellitus, cardiovascular drug use, and other hospitalisations.

resultsOf 5590 patients who experienced an incident MI, 717 (12.8%) experienced at least one further MI. Only 7.7% of patients used statins after an MI during the study period. Compared with those not taking statins, those who had 80% or better adherence to statin treatment had an adjusted relative risk of recurrent MI of 0.19 (95% confidence interval (CI) 0.08 to 0.47) and all cause mortality of 0.47 (95% CI 0.22 to 0.99). There was no significant reduction in either end point for those who were less than 80% adherent to statins.

conclusionsDespite the infrequent use of statin during the study period, good adherence to statin treatment was associated with lower risk of recurrent MI.

Indexed as

AdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPatient CompliancePatient ReadmissionProportional Hazards ModelsRecurrenceRegression AnalysisHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID12181210

DOI10.1136/heart.88.3.229

PMCPMC1767352

OpenAlexW2115316104

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

NCT01770210ClinicalTrials.gov

NCT03973931ClinicalTrials.gov

NCT04458766ClinicalTrials.gov

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.