ArticleEuropean journal of clinical nutrition2002
Effects of dietary fatty acids on the composition and oxidizability of low-density lipoprotein.
Article in European journal of clinical nutrition, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials.Nutrition journal · 2017Pooled it
- Increase in adipose tissue linoleic acid of US adults in the last half century.Advances in nutrition (Bethesda, Md.) · 2015Pooled it
- Effect of alpha linolenic acid on cardiovascular risk markers: a systematic review.Heart (British Cardiac Society) · 2006Pooled it
- Effects of high-fat and low-fat diets rich in monounsaturated fatty acids on serum lipids, LDL size and indices of lipid peroxidation in healthy non-obese men and women when consumed under controlled conditions.European journal of nutrition · 2011Trial
- Effects of dietary cold-pressed turnip rapeseed oil and butter on serum lipids, oxidized LDL and arterial elasticity in men with metabolic syndrome.Lipids in health and disease · 2010Trial
- Influence of three rapeseed oil-rich diets, fortified with alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on the composition and oxidizability of low-density lipoproteins: results of a controlled study in healthy volunteers.European journal of clinical nutrition · 2007Trial
- Mediterranean diet has no effect on markers of inflammation and metabolic risk factors in patients with coronary artery disease.European journal of clinical nutrition · 2006Trial
- High fat diet and PCSK9 knockout modulates lipid profile of the liver and changes the expression of lipid homeostasis related genes.Nutrition & metabolism · 2023Article
- Quality evaluation of oil by cold-pressed peanut from different growing regions in China.Food science & nutrition · 2022Article
- Modulation of endothelium function by fatty acids.Molecular and cellular biochemistry · 2022Review
- The health effects of soy: A reference guide for health professionals.Frontiers in nutrition · 2022Review
- Advances in Crop Improvement and Delivery Research for Nutritional Quality and Health Benefits of Groundnut (Frontiers in plant science · 2020Review
- Comparing the simultaneous determination of cis- and trans-palmitoleic acid in fish oil using HPLC and GC.Lipids in health and disease · 2019Article
- Article
- Health benefits and evaluation of healthcare cost savings if oils rich in monounsaturated fatty acids were substituted for conventional dietary oils in the United States.Nutrition reviews · 2017Article
- The Impact of Macronutrients on Retinal Microvasculature among Singapore Pregnant Women during the Mid-Late Gestation.PloS one · 2016Observational
- Article
- Evidence of health benefits of canola oil.Nutrition reviews · 2013Review
- Effect of dietary fatty acids on serum parameters, fatty acid compositions, and liver histology in Shaoxing laying ducks.Journal of Zhejiang University. Science. B · 2011Article
- Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet.Lipids in health and disease · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study was to compare the effects of dietary monounsaturated fatty acids (MUFA), n-6 and n-3 polyunsaturated fatty acids (PUFA) on LDL composition and oxidizability. DESIGN, SETTING AND SUBJECTS: Sixty-nine healthy young volunteers, students at a nearby college, were included. Six subjects withdrew because of intercurrent illness and five withdrew because they were unable to comply with the dietary regimen.
interventionsThe participants received a 2-week wash-in diet rich in saturated fatty acids (SFA) followed by diets rich in refined olive oil, rapeseed oil or sunflower oil for 4 weeks. Intakes of vitamin E and other antioxidants did not differ significantly between the diets.
resultsAt the end of the study, LDL oxidizability was lowest in the olive oil group (lag time: 72.6 min), intermediate in the rapeseed oil group (68.2 min) and highest in the sunflower oil group (60.4 min, P<0.05 for comparison of all three groups). Despite wide variations in SFA intake, the SFA content of LDL was not statistically different between the four diets (25.8-28.5% of LDL fatty acids). By contrast, the PUFA (43.5%-60.5% of LDL fatty acids) and MUFA content of LDL (13.7-29.1% of LDL fatty acids) showed a wider variability dependent on diet.
conclusionsEnrichment of LDL with MUFA reduces LDL susceptibility to oxidation. As seen on the rapeseed oil diet this effect is independent of a displacement of higher unsaturated fatty acids from LDL. Evidence from this diet also suggests that highly unsaturated n-3 fatty acids in moderate amounts do not increase LDL oxidizability when provided in the context of a diet rich in MUFA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.