Trial reportControlled clinical trials2001
The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT): clinical center recruitment experience.
Trial report in Controlled clinical trials, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00000542. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
Who cites it
20 citing papers in PubMed, 311 citations in OpenAlex.
- Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults: The ALLHAT-LLT Randomized Clinical Trial.JAMA internal medicine · 2017Trial
- Risk of hospitalized gastrointestinal bleeding in persons randomized to diuretic, ACE-inhibitor, or calcium-channel blocker in ALLHAT.Journal of clinical hypertension (Greenwich, Conn.) · 2013Trial
- The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study.Pharmacogenetics and genomics · 2009 · on this mapTrial
- Blood pressure control by drug group in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).Journal of clinical hypertension (Greenwich, Conn.) · 2008Trial
- Interactions between the single nucleotide polymorphisms in the homocysteine pathway (MTHFR 677C>T, MTHFR 1298 A>C, and CBSins) and the efficacy of HMG-CoA reductase inhibitors in preventing cardiovascular disease in high-risk patients of hypertension: the GenHAT study.Pharmacogenetics and genomics · 2008 · on this mapTrial
- Understanding organizational perspectives from clinical research stakeholders involved in recruitment for biopharmaceutical-sponsored clinical trials in the United States: Recommendations for organizational initiatives to improve access and inclusivity in clinical research.Contemporary clinical trials communications · 2023Article
- Inclusion of special populations in clinical research: important considerations and guidelines.Journal of clinical and translational research · 2018Article
- Article
- Recruitment strategies and challenges in a large intervention trial: Systolic Blood Pressure Intervention Trial.Clinical trials (London, England) · 2016Article
- Recruitment and Screening for the Testosterone Trials.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Site selection in community-based clinical trials for substance use disorders: strategies for effective site selection.The American journal of drug and alcohol abuse · 2011Article
- Recruitment and retention strategies for minority or poor clinical research participants: lessons from the Healthy Aging in Neighborhoods of Diversity across the Life Span study.The Gerontologist · 2011Article
- Participation in research studies: factors associated with failing to meet minority recruitment goals.Annals of epidemiology · 2007Article
- A quasi-experimental test of an intervention to increase the use of thiazide-based treatment regimens for people with hypertension.Implementation science : IS · 2007Article
- Absence of an interaction between the angiotensin-converting enzyme insertion-deletion polymorphism and pravastatin on cardiovascular disease in high-risk hypertensive patients: the Genetics of Hypertension-Associated Treatment (GenHAT) study.American heart journal · 2007Article
- Improving Hawaiian and Filipino involvement in clinical research opportunities: qualitative findings from Hawai'i.Ethnicity & disease · 2005Article
- Evidence from clinical trials: can we do better?NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2004Review
- Clinical trial performance of community- vs university-based practices in the submacular surgery trials (SST): SST report no. 2.Archives of ophthalmology (Chicago, Ill. : 1960) · 2004Article
- Optimal treatment of hypertension and cardiovascular risk reduction in African Americans: treatment approaches for outpatients.Journal of clinical hypertension (Greenwich, Conn.)Article
- Effects of stress and behavioral interventions in hypertension: the rise and fall of omapatrilat.Journal of clinical hypertension (Greenwich, Conn.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 11 institutions in 2 countries.
Funding
Abstract
The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is a randomized clinical outcome trial of antihypertensive and lipid-lowering therapy in a diverse population (including substantial numbers of women and minorities) of 42,419 high-risk hypertensives aged > or = 55 years with a planned mean follow-up of 6 years. In this paper, we describe our experience in the identification, recruitment, and selection of clinical centers for this large simple trial capable of meeting the recruitment goals outlined for ALLHAT, and we highlight factors associated with clinical center performance. Over 135,000 recruitment brochures were mailed to physicians. Requests for information and application packets were received from 9351 (6.8%) interested investigators. A total of 1053 completed applications were received and 909 sites (86%) were eventually approved to join the trial. Of the approved sites, 278 either later declined participation or were never activated, and 8 were closed within a year for lack of enrollment. The final 623 randomizing centers exceeded the trial's recruitment goal to enroll at least 40,000 participants into the trial, although the recruitment period was extended 1.5 years longer than planned. Fewer than a quarter of the sites (22.6%) were recruited from academic medical centers or Department of Veterans Affairs Medical Centers. More than half of the sites (54.7%) were private solo or group practices, which contributed 53% of randomized participants. Community health centers comprised about 8% of the ALLHAT sites and 2.9% were part of health maintenance organizations. More than 22% of the principal investigators reported that they had no previous clinical research experience. In summary, ALLHAT was successful in recruiting a diverse group of clinical centers to achieve its patient recruitment goals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.