← Statins × all-cause mortality

TrialJAMA2002

Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT).

ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack TrialPubMed ↗Publisher ↗

The primary results report of NCT00000542.

What the trial testedas reported · 10,365 people · 2002

Range includes no effect

No clear effect on deaths

−1%−11% to +11%

Smaller than almost all for all-cause mortality

As reported

RR 0.99, 95% CI 0.89–1.11 · the paper's word: All-cause mortality

One number in the abstract

the abstract, start to end

… for the 2 groups (relative risk [RR], 0.99; 95% confidence interval [CI], …

← favours treatmentfavours comparator →
could be chance
All-cause mortality
RR 0.990.89–1.11
StatinsAll-cause mortality

Statins × all-cause mortalityhelps?mixed

unlikelylikely
0.500.50 without it
← favours treatmentfavours comparator →
more certainless certain
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370 papers cite itlatest 60 shown

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this paperpooled ittrialcites it

2 trials

NCT00000542phase 31993this paper is its primary reportNCT01713920phase 468 enrolled2010
Full record →Abstract, authors, funding and every citing paper · PMID 12479764