ArticleProceedings of the National Academy of Sciences of the United States of America1999
Allelic association between marker loci.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
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- PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients.BMC medical genetics · 2012Article
- Inherited, familial and sporadic primary open-angle glaucoma.Journal of the National Medical Association · 2007Article
- Assessing the relative ages of admixture in the bovine hybrid zones of Africa and the Near East using X chromosome haplotype mosaicism.Genetics · 2006Article
- Distribution of genome-wide linkage disequilibrium based on microsatellite loci in the Samoan population.Human genomics · 2004Article
- Markers informative for ancestry demonstrate consistent megabase-length linkage disequilibrium in the African American population.Human genetics · 2003Article
- Linkage disequilibrium in human populations.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Human genetics of common mycobacterial infections.Immunologic research · 2003Review
- Article
- Genetic isolates in East Asia: a study of linkage disequilibrium in the X chromosome.American journal of human genetics · 2002Article
- Homozygosity and linkage disequilibrium.Genetics · 2002Article
- Nucleotide diversity and haplotype structure of the human angiotensinogen gene in two populations.American journal of human genetics · 2002Article
- Genomewide scans of complex human diseases: true linkage is hard to find.American journal of human genetics · 2001Article
- Pharmacogenomics, ethnicity, and susceptibility genes.The pharmacogenomics journal · 2001Article
- Article
- Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland.American journal of human genetics · 2000Article
- Predicting the range of linkage disequilibrium.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Genetic epidemiology of single-nucleotide polymorphisms.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Effects of worldwide population subdivision on ALDH2 linkage disequilibrium.Genome research · 1999Article
- Genetic isolates: separate but equal?Proceedings of the National Academy of Sciences of the United States of America · 1999Article
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Abstract
Allelic association has proven useful to refine the location of major genes prior to positional cloning, but it is of uncertain value for genome scans in complex inheritance. We have extended kinship theory to give information content for linkage and allelic association. Application to pairs of closely linked markers as a surrogate for marker x oligogene pairs indicates that association is largely determined by regional founders, with little effect of subsequent demography. Sub-Saharan Africa has the least allelic association, consistent with settlement of other regions by small numbers of founders. Recent speculation about substantial advantages of isolates over large populations, of constant size over expansion, and of F1 hybrids over incrosses is not supported by theory or data. On the contrary, fewer affected cases, less opportunity for replication, and more stochastic variation tend to make isolates less informative for allelic association, as they are for linkage.
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