ArticleProceedings of the National Academy of Sciences of the United States of America1999
Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor alpha-regulated gene expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 75 citations in OpenAlex.
- Review
- The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis.Cell & bioscience · 2024Review
- Deciphering the Roles of PPARγ in Adipocytes via Dynamic Change of Transcription Complex.Frontiers in endocrinology · 2018Review
- Steroid receptor coactivator-2 is a dual regulator of cardiac transcription factor function.The Journal of biological chemistry · 2014Article
- Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.Cell metabolism · 2012Article
- The transcriptional coactivators p/CIP and SRC-1 control insulin resistance through IRS1 in obesity models.PloS one · 2012Article
- Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice.The American journal of pathology · 2011Article
- Transcription coactivator mediator subunit MED1 is required for the development of fatty liver in the mouse.Hepatology (Baltimore, Md.) · 2011Article
- Article
- PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1.Nuclear receptor signaling · 2010Review
- PPARalpha: energy combustion, hypolipidemia, inflammation and cancer.Nuclear receptor signaling · 2010Review
- Transcription coactivator PBP/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse.Carcinogenesis · 2010Article
- PRIC295, a Nuclear Receptor Coactivator, Identified from PPARα-Interacting Cofactor Complex.PPAR research · 2010Article
- Coactivators in PPAR-Regulated Gene Expression.PPAR research · 2010Article
- Redundant enhancement of mouse constitutive androstane receptor transactivation by p160 coactivator family members.Archives of biochemistry and biophysics · 2007Article
- Article
- Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis.The Journal of clinical investigation · 2006Review
- Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Peroxisome proliferators and peroxisome proliferator-activated receptor alpha: biotic and xenobiotic sensing.The American journal of pathology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors, and it is assumed that the biological effects of these receptors depend on interactions with recently identified coactivators, including steroid receptor coactivator-1 (SRC-1). We assessed the in vivo function of SRC-1 on the PPARalpha-regulated gene expression in liver by generating mice in which the SRC-1 gene was inactivated by gene targeting. The homozygous (SRC-1(-/-)) mice were viable and fertile and exhibited no detectable gross phenotypic defects. When challenged with a PPARalpha ligand, such as ciprofibrate or Wy-14,643, the SRC-1(-/-) mice displayed typical pleiotropic responses, including hepatomegaly, peroxisome proliferation in hepatocytes, and increased mRNA and protein levels of genes that are regulated by PPARalpha. These alterations were indistinguishable from those exhibited by SRC-1(+/+) wild-type mice fed either ciprofibrate- or Wy-14, 643-containing diets. These results indicate that SRC-1 is not essential for PPARalpha-mediated transcriptional activation in vivo and suggest redundancy in nuclear receptor coactivators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.