ArticleProceedings of the National Academy of Sciences of the United States of America1999
The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers, 1 of them a synthesis that pooled it.
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Who cites it
172 citing papers in PubMed, 1 synthesis or guideline pooled it, 592 citations in OpenAlex.
- Increased salt tolerance with overexpression of cation/proton antiporter 1 genes: a meta-analysis.Plant biotechnology journal · 2017Pooled it
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- Genome-wide identification and salt stress-induced expression analysis of the NHX gene family in peanut (Arachis hypogaea L.).BMC plant biology · 2026Article
- Engineering resilient roses: molecular insights into biotic and abiotic stress adaptation.Horticulture research · 2026Article
- Overexpression ofGM crops & food · 2025Article
- Cloning and Functional Verification of Salt Tolerance GenePlants (Basel, Switzerland) · 2025Article
- ZxNHX1 from a xerophyte outperforms AtNHX1 in sequestering NaPlant biotechnology journal · 2025Article
- Genome-Wide Identification of theInternational journal of molecular sciences · 2025Article
- Genome-wide identification of NHX gene family and effects of salicylic acid in regulating antioxidant activity as well as nutrients deposition under salt stress in three Brassica species.BMC plant biology · 2025Article
- Linking endo-lysosomal pH, sterol, and trafficking to neurodegenerative disease.FEMS yeast research · 2025Review
- Genome-wide characterization of the CPA gene family in potato and a preliminary functional analysis of its role in NaCl tolerance.BMC genomics · 2024Article
- RNA-Seq-Based WGCNA and Association Analysis Reveal the Key Regulatory Module and Genes Responding to Salt Stress in Wheat Roots.Plants (Basel, Switzerland) · 2024Article
- Genome-wide identification and drought stress-induced expression analysis of theFrontiers in genetics · 2024Article
- Genome-wide identification and expression analysis ofPlant direct · 2023Article
- Yeast Heterologous Expression Systems for the Study of Plant Membrane Proteins.International journal of molecular sciences · 2023Review
- Genome-wide identification and expression analysis of theFrontiers in plant science · 2023Article
- Endosomal Acid-Base Homeostasis in Neurodegenerative Diseases.Reviews of physiology, biochemistry and pharmacology · 2023Article
- Current Methods to Unravel the Functional Properties of Lysosomal Ion Channels and Transporters.Cells · 2022Review
- Evolutionary Significance of NHX Family and NHX1 in Salinity Stress Adaptation in the GenusInternational journal of molecular sciences · 2022Article
112 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Overexpression of the Arabidopsis thaliana vacuolar H+-pyrophosphatase (AVP1) confers salt tolerance to the salt-sensitive ena1 mutant of Saccharomyces cerevisiae. Suppression of salt sensitivity requires two ion transporters, the Gef1 Cl- channel and the Nhx1 Na+/H+ exchanger. These two proteins colocalize to the prevacuolar compartment of yeast and are thought to be required for optimal acidification of this compartment. Overexpression of AtNHX1, the plant homologue of the yeast Na+/H+ exchanger, suppresses some of the mutant phenotypes of the yeast nhx1 mutant. Moreover, the level of AtNHX1 mRNA in Arabidopsis is increased in the presence of NaCl. The regulation of AtNHX1 by NaCl and the ability of the plant gene to suppress the yeast nhx1 mutant suggest that the mechanism by which cations are detoxified in yeast and plants may be similar.
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