ArticleProceedings of the National Academy of Sciences of the United States of America1999
Receptor-induced polymerization of coatomer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 73 citations in OpenAlex.
- Article
- Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway.Science advances · 2024Article
- Solid-State NMR Investigations of the MHC II Transmembrane Domains: Topological Equilibria and Lipid Interactions.The Journal of membrane biology · 2019Article
- A Novel Glycoproteomics Workflow Reveals Dynamic O-GlcNAcylation of COPγ1 as a Candidate Regulator of Protein Trafficking.Frontiers in endocrinology · 2018Article
- Structural characterization of coatomer in its cytosolic state.Protein & cell · 2016Article
- p24 family proteins: key players in the regulation of trafficking along the secretory pathway.Protoplasma · 2016Review
- Molecular recognition of a single sphingolipid species by a protein's transmembrane domain.Nature · 2012Article
- COPI budding within the Golgi stack.Cold Spring Harbor perspectives in biology · 2011Review
- Essential lysine residues within transmembrane helix 1 of diphtheria toxin facilitate COPI binding and catalytic domain entry.Molecular microbiology · 2010Article
- Following the fate in vivo of COPI vesicles generated in vitro.Traffic (Copenhagen, Denmark) · 2009Article
- Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking.The Journal of cell biology · 2008Article
- Cargo-sorting signals promote polymerization of adaptor protein-1 in an Arf-1.GTP-independent manner.Archives of biochemistry and biophysics · 2008Article
- Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins.Molecular and cellular biology · 2006Article
- The Gcs1 Arf-GAP mediates Snc1,2 v-SNARE retrieval to the Golgi in yeast.Molecular biology of the cell · 2006Article
- COPI-mediated transport.The Journal of membrane biology · 2006Review
- Oligomerization and dissociation of AP-1 adaptors are regulated by cargo signals and by ArfGAP1-induced GTP hydrolysis.Molecular biology of the cell · 2005Article
- ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation.The Journal of cell biology · 2005Article
- Generation of nonidentical compartments in vesicular transport systems.The Journal of cell biology · 2005Article
- Suppression of coatomer mutants by a new protein family with COPI and COPII binding motifs in Saccharomyces cerevisiae.Molecular biology of the cell · 2003Article
- ARF1.GTP, tyrosine-based signals, and phosphatidylinositol 4,5-bisphosphate constitute a minimal machinery to recruit the AP-1 clathrin adaptor to membranes.Molecular biology of the cell · 2002Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coatomer, the coat protein complex of COPI vesicles, is involved in the budding of these vesicles, but the underlying mechanism is unknown. Toward a better understanding of this process, the interaction between coatomer and the cytoplasmic domain of a major transmembrane protein of COPI vesicles, p23, was studied. Interaction of coatomer with this peptide domain results in a conformational change and polymerization of the complex in vitro. This changed conformation also is observed in vivo, i.e., on the surface of authentic, isolated COPI vesicles. An average of four peptides was found associated with one coatomer complex after polymerization. Based on these results, we propose a mechanism by which the induced conformational change of coatomer results in its polymerization, and thus drives formation of the bud on the Golgi membrane during biogenesis of a COPI vesicle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.