ArticleThe Journal of experimental medicine1999
Commitment to the B lymphoid lineage occurs before DH-JH recombination.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 132 citations in OpenAlex.
- IL-33/ST2 signaling in ILC2s drives exhaustion and myeloid skewing of HSCs in response to hematopoietic stress and aging.iScience · 2025Article
- Type I interferon induced during chronic viral infection favors B-cell development in the thymus.Immunology and cell biology · 2024Article
- An Update on the Evolutionary History of Bregs.Genes · 2022Review
- The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B Cells.Frontiers in immunology · 2022Article
- TCRCell · 2021Article
- Functional definition of a transcription factor hierarchy regulating T cell lineage commitment.Science advances · 2020Article
- Relevance of PSGL-1 Expression in B Cell Development and Activation.Frontiers in immunology · 2020Article
- Immunophenotyping of Murine Precursor B-Cell Leukemia/Lymphoma: A Comparison of Immunohistochemistry and Flow Cytometry.Veterinary pathology · 2019Article
- Sirtuins in B lymphocytes metabolism and function.World journal of experimental medicine · 2019Review
- Toll-like receptor 9 and interferon-γ receptor signaling suppress the B-cell fate of uncommitted progenitors in mice.European journal of immunology · 2015Article
- The effects of diet-induced obesity on B cell function.Clinical and experimental immunology · 2015Review
- The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function.Immunological reviews · 2014Review
- Accumulation of prelamin A compromises NF-κB-regulated B-lymphopoiesis in a progeria mouse model.Longevity & healthspan · 2013Article
- Separation of plasmacytoid dendritic cells from B-cell-biased lymphoid progenitor (BLP) and Pre-pro B cells using PDCA-1.PloS one · 2013Article
- IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Effects of acute and chronic inflammation on B-cell development and differentiation.The Journal of investigative dermatology · 2009Review
- Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells.Journal of leukocyte biology · 2008Article
- Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia.Blood · 2007Article
- Antisense intergenic transcription precedes Igh D-to-J recombination and is controlled by the intronic enhancer Emu.Molecular and cellular biology · 2007Article
- Novel insights into the pathogenesis of the Graffi murine leukemia retrovirus.Journal of virology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Lineage commitment in B lymphopoiesis remains poorly understood due to the inability to clearly define newly committed B lineage progenitors and their multipotential descendants. We examined the potential of three recently described progenitor populations in adult mouse bone marrow to differentiate into each hematopoietic lineage. The earliest of these, termed fraction (Fr.) A0, exhibited myeloid, erythroid, and B and T lymphoid progenitor activity and included individual cells with myeloid/B lymphoid potential. In sharp contrast, two later populations, termed Frs. A1 and A2 and characterized by surface B220 expression and transcription of the germline immunoglobulin heavy chain (IgH) locus, lacked progenitor activity for all hematopoietic lineages except B lymphocytes. These observations, together with single cell polymerase chain reaction analysis showing a lack of DHJH rearrangements in each population and experiments showing identical precursor potentials when these populations were derived from recombination activating gene (Rag)-1(-/-) and JH-/- mice, demonstrate that commitment to the B lymphoid lineage occurs before and independently of VHDHJH recombination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.