ArticleOncogene1999
Localization of a novel tumor suppressor gene associated with human oral cancer on chromosome 4q25.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Novel APC gene mutations associated with protein alteration in diffuse type gastric cancer.BMC medical genetics · 2017Article
- Genetic gains and losses in oral squamous cell carcinoma: impact on clinical management.Cellular oncology (Dordrecht, Netherlands) · 2014Article
- Gene expression in uninvolved oral mucosa of OSCC patients facilitates identification of markers predictive of OSCC outcomes.PloS one · 2012Article
- DNA methylation and carcinogenesis of PRDM5 in cervical cancer.Journal of cancer research and clinical oncology · 2010Article
- Tumor suppress genes screening analysis on 4q in sporadic colorectal carcinoma.World journal of gastroenterology · 2008Article
- Localization of a susceptibility locus for hepatocellular carcinoma to chromosome 4q in a hepatitis B hyperendemic area.Oncogene · 2006Article
- Article
- Functional evidence for a squamous cell carcinoma mortality gene(s) on human chromosome 4.Oncogene · 2002Article
- Apoptotic threshold is lowered by p53 transactivation of caspase-6.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Analysis of the ANA gene as a candidate for the chromosome 21q oral cancer susceptibility locus.British journal of cancer · 2001Article
- A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23.Neoplasia (New York, N.Y.)Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent cytogenetic and molecular studies with highly polymorphic microsatellite markers have implicated allele loss involving chromosome 4 in several human cancers, which suggests the presence of multiple tumor suppressor gene (TSG) loci. However, there has been no detailed analysis of loss of heterozygosity (LOH) on chromosome 4 in oral squamous cell carcinoma (OSCC). To determine the location of a putative TSG associated with OSCC on chromosome 4, polymerase chain reaction (PCR) analysis of microsatellite polymorphisms corresponding to 17 loci was performed to screen 32 patients with OSCC. LOH was observed in the majority of the tumors (75%) in at least one of the loci. The loci on the long arm exhibited a significantly higher frequency of deletions (66%) than those of the short arm (25%). Among the loci tested, frequent LOH was centered at D4S1573 on 4q25, which represents a region of about 4 centimorgans (cM). However, no commonly deleted regions were found on the short arm of the chromosome. We detected microsatellite instability (MI) in 31% of the cases. MI was also observed more frequently on the long arm (28%) than the short arm (6%). Thus, our data indicate that alterations of chromosome 4 regions, especially the long arm, are associated with OSCC tumorigenesis and that the 4q25 region may harbor at least one putative TSG.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.