ArticleThe European journal of neuroscience1999
TrkA activation in the rat visual cortex by antirat trkA IgG prevents the effect of monocular deprivation.
Article in The European journal of neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Genotype, resilience and function and physical activity post hip fracture.International journal of orthopaedic and trauma nursing · 2019Article
- Activity-Dependent Inhibitory Synaptogenesis in Cerebellar Cultures.Brain plasticity (Amsterdam, Netherlands) · 2016Review
- The changeable nervous system: studies on neuroplasticity in cerebellar cultures.Neuroscience and biobehavioral reviews · 2014Review
- Article
- Nerve growth factor regulates the firing patterns and synaptic composition of motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Insulin-like growth factor 1 (IGF-1) mediates the effects of enriched environment (EE) on visual cortical development.PloS one · 2007Article
- A novel endocytic recycling signal distinguishes biological responses of Trk neurotrophin receptors.Molecular biology of the cell · 2005Article
- Nerve growth factor favours long-term depression over long-term potentiation in layer II-III neurones of rat visual cortex.The Journal of physiology · 2004Article
- Expression of the nerve growth factor receptors TrkA and p75NTR in the visual cortex of the rat: development and regulation by the cholinergic input.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Article
- Effects of neurotrophins on cortical plasticity: same or different?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
It has been recently shown that intraventricular injections of nerve growth factor (NGF) prevent the effects of monocular deprivation in the rat. We have tested the localization and the molecular nature of the NGF receptor(s) responsible for this effect by activating cortical trkA receptors in monocularly deprived rats by cortical infusion of a specific agonist of NGF on trkA, the bivalent antirat trkA IgG (RTA-IgG). TrkA protein was detected by immunoblot in the rat visual cortex during the critical period. Rats were monocularly deprived for 1 week (P21-28) and RTA-IgG or control rabbit IgG were delivered by osmotic minipumps. The effects of monocular deprivation on the ocular dominance of visual cortical neurons were assessed by extracellular single cell recordings. We found that the shift towards the ipsilateral, non-deprived eye was largely prevented by RTA-IgG. Infusion of RTA-IgG combined with antibody that blocks p75NTR (REX), slightly reduced RTA-IgG effectiveness in preventing monocular deprivation effects. These results suggest that NGF action in visual cortical plasticity is mediated by cortical TrkA receptors with p75NTR exerting a facilitatory role.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.