ArticleJournal of clinical microbiology1999
Cholera in Vietnam: changes in genotypes and emergence of class I integrons containing aminoglycoside resistance gene cassettes in vibrio cholerae O1 strains isolated from 1979 to 1996.
Article in Journal of clinical microbiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 74 citations in OpenAlex.
- Multidrug Resistance, Biofilm-Forming Ability, and Molecular Characterization ofAntibiotics (Basel, Switzerland) · 2025Article
- Phage predation, disease severity and pathogen genetic diversity in cholera patients.bioRxiv : the preprint server for biology · 2024Article
- Vibrio cholerae O139 genomes provide a clue to why it may have failed to usher in the eighth cholera pandemic.Nature communications · 2022Article
- Antibiotic Resistance Conferred by Class 1 Integron in Vibrio Cholerae Strains: A Meta-analysis.The East African health research journal · 2022Review
- Integrative and Conjugative Elements-PositiveFrontiers in microbiology · 2019Article
- Cholera returns to southern Vietnam in an outbreak associated with consuming unsafe water through iced tea: A matched case-control study.PLoS neglected tropical diseases · 2017Article
- Insights into Bacteriophage Application in Controlling Vibrio Species.Frontiers in microbiology · 2016Review
- Oral cholera vaccine development and use in Vietnam.PLoS medicine · 2014Review
- Multi-drug resistant Vibrio cholerae O1 variant El Tor isolated in northern Vietnam between 2007 and 2010.Journal of medical microbiology · 2012Article
- Antibiotic susceptibility profiles of some Vibrio strains isolated from wastewater final effluents in a rural community of the Eastern Cape Province of South Africa.BMC microbiology · 2010Article
- Diverse tetracycline resistant bacteria and resistance genes from coastal waters of Jiaozhou Bay.Microbial ecology · 2008Article
- Temporal trends and climatic factors associated with bacterial enteric diseases in Vietnam, 1991-2001.Environmental health perspectives · 2008Article
- Multiply antibiotic-resistant Vibrio cholerae O1 biotype El Tor strains emerge during cholera outbreaks in Zambia.Epidemiology and infection · 2007Article
- New cluster of plasmid-located class 1 integrons in Vibrio cholerae O1 and a dfrA15 cassette-containing integron in Vibrio parahaemolyticus isolated in Angola.Antimicrobial agents and chemotherapy · 2006Article
- Antibiotic resistance conferred by a class I integron and SXT constin in Vibrio cholerae O1 strains isolated in Laos.Antimicrobial agents and chemotherapy · 2004Article
- Versatility of aminoglycosides and prospects for their future.Clinical microbiology reviews · 2003Review
- Class I integrons and SXT elements in El Tor strains isolated before and after 1992 Vibrio cholerae O139 outbreak, Calcutta, India.Emerging infectious diseases · 2003Article
- Occurrence of antibiotic resistance gene cassettes aac(6')-Ib, dfrA5, dfrA12, and ereA2 in class I integrons in non-O1, non-O139 Vibrio cholerae strains in India.Antimicrobial agents and chemotherapy · 2002Article
- Detection of RTX toxin gene in Vibrio cholerae by PCR.Journal of clinical microbiology · 2001Article
- Class 1 integron-borne, multiple-antibiotic resistance encoded by a 150-kilobase conjugative plasmid in epidemic vibrio cholerae O1 strains isolated in Guinea-Bissau.Journal of clinical microbiology · 2000Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of cholera cases and the mortality rates reported from different regions of Vietnam varied considerably in the period from 1979 to 1996, with between 2,500 and 6,000 cases reported annually from 1992 to 1995. Annual mortality rates ranged from 2.0 to 9.6% from 1979 to 1983 to less than 1.8% after 1983. Major cholera outbreaks were reported from the High Plateau region for the first time in 1994 and 1995; this is an area with limited access to health services and safe drinking-water supplies. All cases were associated with Vibrio cholerae O1. Using ribotyping, cholera toxin (CT) genotyping, and characterization of antibiotic susceptibility patterns and antibiotic resistance genes by PCR, we show that strains isolated after 1990 were clearly different from strains isolated before 1991. In contrast to strains isolated before 1991, 94% of 104 strains isolated after 1990 showed an identical ribotype R1, were resistant to sulfamethoxazole and streptomycin, and showed a different CT genotype. Furthermore, PCR analysis revealed that sulfamethoxazole-resistant strains harbored class I integrons containing a gene cassette ant(3")-1a encoding resistance to streptomycin and spectinomycin. This is, to our knowledge, the first report of class I integrons in V. cholerae. The development of cholera and the changes in the phenotypic and genotypic properties of V. cholerae O1 shown in the present study highlight the importance of monitoring V. cholerae O1 in Vietnam as in other parts of the world. In particular, the emergence of the new ribotype R1 strain containing class I integrons should be further studied.
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