ArticleJournal of clinical microbiology1999
Serologic testing for human granulocytic ehrlichiosis at a national referral center.
Article in Journal of clinical microbiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 97 citations in OpenAlex.
- AcuteOpen forum infectious diseases · 2024Article
- Under-diagnosis of vector-borne diseases among individuals suspected of having Scrub Typhus in South Korea.PloS one · 2023Article
- Infective endocarditis caused byIDCases · 2021Article
- High Seroprevalence ofThe American journal of tropical medicine and hygiene · 2019Article
- Article
- Control of Lyme borreliosis and other Ixodes ricinus-borne diseases.Parasites & vectors · 2018Review
- A Bayesian spatio-temporal model for forecasting the prevalence of antibodies to Ehrlichia species in domestic dogs within the contiguous United States.Parasites & vectors · 2017Article
- Increasing Incidence of Ehrlichiosis in the United States: A Summary of National Surveillance of Ehrlichia chaffeensis and Ehrlichia ewingii Infections in the United States, 2008-2012.The American journal of tropical medicine and hygiene · 2016Article
- Human Infection with Ehrlichia muris-like Pathogen, United States, 2007-2013(1).Emerging infectious diseases · 2015Article
- Comparison of a real-time PCR method with serology and blood smear analysis for diagnosis of human anaplasmosis: importance of infection time course for optimal test utilization.Journal of clinical microbiology · 2013Article
- Anaplasma odocoilei sp. nov. (family Anaplasmataceae) from white-tailed deer (Odocoileus virginianus).Ticks and tick-borne diseases · 2013Article
- Epidemiology of ehrlichiosis and anaplasmosis among American Indians in the United States, 2000-2007.The American journal of tropical medicine and hygiene · 2012Article
- Increasing incidence of Ehrlichia chaffeensis and Anaplasma phagocytophilum in the United States, 2000-2007.The American journal of tropical medicine and hygiene · 2011Article
- Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis.Clinical and vaccine immunology : CVI · 2010Article
- Co-circulating microorganisms in questing Ixodes scapularis nymphs in Maryland.Journal of vector ecology : journal of the Society for Vector Ecology · 2007Article
- Experimental infection of white-tailed deer with Anaplasma phagocytophilum, etiologic agent of human granulocytic anaplasmosis.Journal of clinical microbiology · 2005Article
- Reinfection with Anaplasma phagocytophilum in BALB/c mice and cross-protection between two sympatric isolates.Infection and immunity · 2004Article
- Human monocytotropic ehrlichiosis, Missouri.Emerging infectious diseases · 2003Article
- Ehrlichia chaffeensis infections among HIV-infected patients in a human monocytic ehrlichiosis-endemic area.Emerging infectious diseases · 2003Article
- Clinical manifestations, epidemiology, and laboratory diagnosis of human monocytotropic ehrlichiosis in a commercial laboratory setting.Clinical and diagnostic laboratory immunology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An indirect immunofluorescence assay (IFA) was used to identify patients with antibodies reactive to the human granulocytic ehrlichiosis (HGE) agent. Serum samples collected from clinically ill individuals were submitted to the Centers for Disease Control and Prevention by physicians via state health departments from throughout the United States and tested against a panel of ehrlichial and rickettsial pathogens. Antibodies reactive to the HGE agent were detected in 142 (8.9%) of 1,602 individuals tested. There were 19 confirmed and 59 probable (n = 78) cases of HGE as defined by seroconversion or a fourfold or higher titer to the HGE agent than to the Ehrlichia chaffeensis antigens. The average age of patients with HGE was 57 years, and males accounted for 53 (68%) of the patients. Cases of HGE occurred in 21 states; 47 (60%) of the cases occurred in Connecticut (n = 14), New York (n = 18), and Wisconsin (n = 15). Onset of HGE was identified from April through December, with cases peaking in June and July. The earliest confirmed cases of HGE occurred in 1987 in Wisconsin and 1988 in Florida. No fatalities were reported among the 78 patients with confirmed or probable HGE. Reactivity to the HGE agent and to either Coxiella burnetii, Rickettsia rickettsii, or Rickettsia typhi was infrequent; however, 74 (52%) of the 142 individuals who were positive for HGE had at least one serum sample that also reacted to the E. chaffeensis antigen. Thirty-four persons with confirmed or probable human monocytic ehrlichiosis due to E. chaffeensis also had antibodies to the HGE agent in at least one serum sample. The specific etiologic agent for 30 patients was not ascribed because of similarity of titers to both ehrlichial antigens. The use of both antigens may be required to correctly diagnose most cases of human ehrlichiosis, especially in geographic regions where both the HGE agent and E. chaffeensis occur.
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