ArticleJournal of virology1999
Measles virus infection induces terminal differentiation of human thymic epithelial cells.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Severe fever with thrombocytopenia syndrome virus infection induces thymic atrophy in IFNARVirulence · 2025Article
- Primary and secondary defects of the thymus.Immunological reviews · 2024Review
- Transcriptomic profiling of thymic dysregulation and viral tropism after neonatal roseolovirus infection.Frontiers in immunology · 2024Article
- SARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity.The Journal of allergy and clinical immunology · 2023Article
- Disruption of thymic central tolerance by infection with murine roseolovirus induces autoimmune gastritis.The Journal of experimental medicine · 2022Article
- Effect of Coxsackievirus B4 Infection on the Thymus: Elucidating Its Role in the Pathogenesis of Type 1 Diabetes.Microorganisms · 2021Review
- T cell regeneration after immunological injury.Nature reviews. Immunology · 2021Review
- Review
- Tolerance has its limits: how the thymus copes with infection.Trends in immunology · 2013Review
- Thymic function is maintained during Salmonella-induced atrophy and recovery.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Immunology in the clinic review series; focus on type 1 diabetes and viruses: enterovirus, thymus and type 1 diabetes pathogenesis.Clinical and experimental immunology · 2012Review
- Immature CD4+CD8+ thymocytes are preferentially infected by measles virus in human thymic organ cultures.PloS one · 2012Article
- Measles virus-induced immunosuppression: from effectors to mechanisms.Medical microbiology and immunology · 2010Review
- Cell-cell fusion induced by measles virus amplifies the type I interferon response.Journal of virology · 2007Article
- The thymus is a common target organ in infectious diseases.PLoS pathogens · 2006Review
- Measles virus (MV) nucleoprotein binds to a novel cell surface receptor distinct from FcgammaRII via its C-terminal domain: role in MV-induced immunosuppression.Journal of virology · 2003Article
- Increased thymic output during acute measles virus infection.Journal of virology · 2003Article
- Interferons mediate terminal differentiation of human cortical thymic epithelial cells.Journal of virology · 2002Article
- Calpain inhibition protects against virus-induced apoptotic myocardial injury.Journal of virology · 2001Article
- Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.Journal of virology · 2000Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Measles virus infection induces a profound immunosuppression that may lead to serious secondary infections and mortality. In this report, we show that the human cortical thymic epithelial cell line is highly susceptible to measles virus infection in vitro, resulting in infectious viral particle production and syncytium formation. Measles virus inhibits thymic epithelial cell growth and induces an arrest in the G0/G1 phases of the cell cycle. Moreover, we show that measles virus induces a progressive thymic epithelial cell differentiation process: attached measles virus-infected epithelial cells correspond to an intermediate state of differentiation while floating cells, recovered from cell culture supernatants, are fully differentiated. Measles virus-induced thymic epithelial cell differentiation is characterized by morphological and phenotypic changes. Measles virus-infected attached cells present fusiform and stellate shapes followed by a loss of cell-cell contacts and a shift from low- to high-molecular-weight keratin expression. Measles virus infection induces thymic epithelial cell apoptosis in terminally differentiated cells, revealed by the condensation and degradation of DNA in measles virus-infected floating thymic epithelial cells. Because thymic epithelial cells are required for the generation of immunocompetent T lymphocytes, our results suggest that measles virus-induced terminal differentiation of thymic epithelial cells may contribute to immunosuppression, particularly in children, in whom the thymic microenvironment is of critical importance for the development and maturation of a functional immune system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.