ArticleJournal of virology1999
vig-1, a new fish gene induced by the rhabdovirus glycoprotein, has a virus-induced homologue in humans and shares conserved motifs with the MoaA family.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 189 citations in OpenAlex.
- Review
- Article
- Viperin and Its Effect on SVCV Replication in Common Carp,Animals : an open access journal from MDPI · 2025Article
- Unexpected regulatory functions of cyprinid Viperin on inflammation and metabolism.BMC genomics · 2024Article
- Viperin-like proteins interfere with RNA viruses in plants.Frontiers in plant science · 2024Article
- Innate immune response of rainbow trout erythrocytes to spinycterins expressing a downsized viral fragment of viral haemorrhagic septicaemia virus.Aquaculture (Amsterdam, Netherlands) · 2023Article
- Comparative Study on Immune Function of the Head and Trunk Kidney in Rainbow Trout Responding to IHNV Infection.Viruses · 2022Article
- Fish Innate Immune Response to Viral Infection-An Overview of Five Major Antiviral Genes.Viruses · 2022Review
- Divergent Antiviral Mechanisms of TwoFrontiers in immunology · 2021Article
- Cellular Immune Responses in Rainbow Trout (Vaccines · 2020Article
- Viperin Reveals Its True Function.Annual review of virology · 2020Review
- Viperin: An ancient radical SAM enzyme finds its place in modern cellular metabolism and innate immunity.The Journal of biological chemistry · 2020Review
- Structural Basis of the Substrate Selectivity of Viperin.Biochemistry · 2020Article
- Genetic and transcriptomic analyses provide new insights on the early antiviral response to VHSV in resistant and susceptible rainbow trout.BMC genomics · 2018Article
- Recent advances in antiviral interferon-stimulated gene biology.F1000Research · 2018Review
- Structural studies of viperin, an antiviral radical SAM enzyme.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Identification of diverse defense mechanisms in rainbow trout red blood cells in response to halted replication of VHS virus.F1000Research · 2017Article
- The Peculiar Characteristics of Fish Type I Interferons.Viruses · 2016Review
- Can VHS Virus Bypass the Protective Immunity Induced by DNA Vaccination in Rainbow Trout?PloS one · 2016Article
- Differential Expression Profile of Chicken Embryo Fibroblast DF-1 Cells Infected with Cell-Adapted Infectious Bursal Disease Virus.PloS one · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used mRNA differential display methodology to analyze the shift of transcription profile induced by the fish rhabdovirus, viral hemorrhagic septicemia virus (VHSV), in rainbow trout leukocytes. We identified and characterized a new gene which is directly induced by VHSV. This VHSV-induced gene (vig-1) encodes a 348-amino-acid protein. vig-1 is highly expressed during the experimental disease in lymphoid organs of the infected fish. Intramuscular injection of a plasmid vector expressing the viral glycoprotein results in vig-1 expression, showing that the external virus protein is sufficient for the induction. vig-1 expression is also obtained by a rainbow trout interferon-like factor, indicating that vig-1 can be induced through different pathways. Moreover, vig-1 is homologous to a recently described human cytomegalovirus-induced gene. Accordingly, vig-1 activation may represent a new virus-induced activation pathway highly conserved in vertebrates. The deduced amino acid sequence of vig-1 is significantly related to sequences required for the biosynthesis of metal cofactors. This suggests that the function of vig-1 may be involved in the nonspecific virus-induced synthesis of enzymatic cofactors of the nitric oxide pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.