ArticleThe Journal of cell biology1999
The intermediate filament protein peripherin is the specific interaction partner of mouse BPAG1-n (dystonin) in neurons.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 90 citations in OpenAlex.
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- Microtubule-associated proteins (MAPs) in microtubule cytoskeletal dynamics and spermatogenesis.Histology and histopathology · 2021Review
- Mammalian Plakins, Giant Cytolinkers: Versatile Biological Functions and Roles in Cancer.International journal of molecular sciences · 2018Review
- Cytoskeletal Linker Protein Dystonin Is Not Critical to Terminal Oligodendrocyte Differentiation or CNS Myelination.PloS one · 2016Article
- Sacs knockout mice present pathophysiological defects underlying autosomal recessive spastic ataxia of Charlevoix-Saguenay.Human molecular genetics · 2015Article
- Dyshidrosiform pemphigoid with Parkinsonism in a nonagenarian Maharashtrian female.Indian dermatology online journal · 2014Article
- Distinct expression of Mas1-related G-protein-coupled receptor B4 in dorsal root and trigeminal ganglia--implications for altered behaviors in acid-sensing ion channel 3-deficient mice.Journal of molecular neuroscience : MN · 2013Article
- Cellular chaperonin CCTγ contributes to rabies virus replication during infection.Journal of virology · 2013Article
- Spectraplakins: master orchestrators of cytoskeletal dynamics.The Journal of cell biology · 2012Review
- Neuronal dystonin isoform 2 is a mediator of endoplasmic reticulum structure and function.Molecular biology of the cell · 2012Article
- Untethering the nuclear envelope and cytoskeleton: biologically distinct dystonias arising from a common cellular dysfunction.International journal of cell biology · 2012Article
- Cardiac autoantibodies from patients affected by a new variant of endemic pemphigus foliaceus in Colombia, South America.Journal of clinical immunology · 2011Article
- Type III intermediate filament peripherin inhibits neuritogenesis in type II spiral ganglion neurons in vitro.Neuroscience letters · 2010Article
- Immunolocalization of fascin, an actin-bundling protein and glial fibrillary acidic protein in human astrocytoma cells.Brain pathology (Zurich, Switzerland) · 2010Article
- The polypeptide composition of moving and stationary neurofilaments in cultured sympathetic neurons.Cell motility and the cytoskeleton · 2007Article
- Elimination of epiplakin by gene targeting results in acceleration of keratinocyte migration in mice.Molecular and cellular biology · 2006Article
- Genetic alterations at the Bpag1 locus in dt mice and their impact on transcript expression.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Maintaining epithelial integrity: a function for gigantic spectraplakin isoforms in adherens junctions.The Journal of cell biology · 2003Article
- Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.Molecular biology of the cell · 2003Article
- Relating interactions between neurofilaments to the structure of axonal neurofilament distributions through polymer brush models.Biophysical journal · 2002Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
The dystonia musculorum (dt) mouse suffers from severe degeneration of primary sensory neurons. The mutated gene product is named dystonin and is identical to the neuronal isoform of bullous pemphigoid antigen 1 (BPAG1-n). BPAG1-n contains an actin-binding domain at its NH2 terminus and a putative intermediate filament-binding domain at its COOH terminus. Because the degenerating sensory neurons of dt mice display abnormal accumulations of intermediate filaments in the axons, BPAG1-n has been postulated to organize the neuronal cytoskeleton by interacting with both the neurofilament triplet proteins (NFTPs) and microfilaments. In this paper we show by a variety of methods that the COOH-terminal tail domain of mouse BPAG1 interacts specifically with peripherin, but in contrast to a previous study (Yang, Y., J. Dowling, Q.C. Yu, P. Kouklis, D.W. Cleveland, and E. Fuchs. 1996. Cell. 86:655-665), mouse BPAG1 fails to associate with full-length NFTPs. The tail domains interfered with the association of the NFTPs with BPAG1. In dt mice, peripherin is present in axonal swellings of degenerating sensory neurons in the dorsal root ganglia and is downregulated even in other neural regions, which have no obvious signs of pathology. Since peripherin and BPAG1-n also display similar expression patterns in the nervous system, we suggest that peripherin is the specific interaction partner of BPAG1-n in vivo.
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