ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 106 citations in OpenAlex.
- HIV Neuropathogenesis in the Presence of a Disrupted Dopamine System.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Review
- Hes1 negatively regulates neurogenesis in the adult mouse dentate gyrus following traumatic brain injury.Experimental and therapeutic medicine · 2018Article
- Differential roles of NaScientific reports · 2018Article
- Febrile seizures.Korean journal of pediatrics · 2014Review
- Adenovirus E1B 19-kilodalton protein modulates innate immunity through apoptotic mimicry.Journal of virology · 2014Article
- The in vivo therapeutic efficacy of the oncolytic adenovirus Delta24-RGD is mediated by tumor-specific immunity.PloS one · 2014Article
- LIGHT/TNFSR14 can regulate hepatic lipase expression by hepatocytes independent of T cells and Kupffer cells.PloS one · 2013Article
- Implications of the innate immune response to adenovirus and adenoviral vectors.Future virology · 2011Article
- Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Gene transfer into rat brain using adenoviral vectors.Current protocols in neuroscience · 2010Article
- Febrile seizures: mechanisms and relationship to epilepsy.Brain & development · 2009Review
- Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation.Endocrinology · 2008Article
- Gene transfer into neural cells in vitro using adenoviral vectors.Current protocols in neuroscience · 2008Article
- Dendritic cell-based immunotherapy for malignant glioma.Neuroscience bulletin · 2008Review
- One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications.Molecular therapy : the journal of the American Society of Gene Therapy · 2007Article
- Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions.Current gene therapy · 2007Review
- Immunology of neurological gene therapy: how T cells modulate viral vector-mediated therapeutic transgene expression through immunological synapses.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2007Review
- Efficacy of nonviral gene transfer in the canine brain.Journal of neurosurgery · 2007Article
- Adenoviral-mediated gene transfer into the canine brain in vivo.Neurosurgery · 2007Article
- Interleukin-1beta contributes to the generation of experimental febrile seizures.Annals of neurology · 2005Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Adenovirus-mediated gene transfer into the brain is associated with significant inflammation and activation of anti-vector and anti-transgene immune responses that curtail the gene delivery of adenoviruses and therapeutic efficacy. Elucidating the molecular mediators of inflammatory and immune responses to adenoviruses injected into the brain should allow us to inhibit their inflammatory actions, thereby reducing vector clearance and enhance adenoviral-mediated gene transfer into the CNS. Cytokines are primary mediators of the immune response and are released during inflammation. Here we report for the first time that injection of replication-deficient adenovirus vectors into the cerebral ventricles of rats causes a rapid increase in body temperature. This fever response precedes any vector-encoded transgene expression and occurs with vectors encoding no transgene, as well as with vectors encoding a therapeutic transgene i.e., HSV1-thymidine kinase. No fever is detected after infection of the striatum, an important brain target in studies on neurodegeneration. After infection of the brain ventricles, CSF levels of immunoreactive tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta increase significantly (up to 300-fold). In the hypothalamus, the locus of thermoregulation in the brain, only IL-1beta and IL-6 are significantly elevated. A neutralizing TNF-alpha antibody has no effect on adenovirus-induced fever. However, pretreatment with either the IL-1 receptor antagonist or the cyclooxygenase inhibitor flurbiprofen completely abolishes adenovirus-induced fever, suggesting that IL-1 and prostaglandins are direct mediators of this response. These results are the first to demonstrate that IL-1, but not TNF-alpha, is the main mediator of a very early inflammatory response to adenovirus in the brain.
Indexed as
Identifiers
9952427PMC6786017W1950980509What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.