ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Odor-induced, activity-dependent transneuronal gene induction in vitro: mediation by NMDA receptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Illuminating and Sniffing Out the Neuromodulatory Roles of Dopamine in the Retina and Olfactory Bulb.Frontiers in cellular neuroscience · 2020Review
- The cellular prion protein promotes olfactory sensory neuron survival and axon targeting during adult neurogenesis.Developmental biology · 2018Article
- Conditional Deletion ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Odorant Sensory Input Modulates DNA Secondary Structure Formation and Heterogeneous Ribonucleoprotein Recruitment on the Tyrosine Hydroxylase and Glutamic Acid Decarboxylase 1 Promoters in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Epigenetic control of neurotransmitter expression in olfactory bulb interneurons.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013Review
- Article
- Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream.Biochemical and biophysical research communications · 2010Article
- gamma-Aminobutyric acid-mediated regulation of the activity-dependent olfactory bulb dopaminergic phenotype.Journal of neuroscience research · 2009Article
- Article
- Developmental regulation of metabotropic glutamate receptor 1 splice variants in olfactory bulb mitral cells.Journal of neuroscience research · 2009Article
- Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system.Molecular and cellular biology · 2005Article
- Odorant-induced activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in the olfactory bulb promotes survival of newly formed granule cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Plasticity in the olfactory system: lessons for the neurobiology of memory.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2004Review
- Phenotypic differentiation during migration of dopaminergic progenitor cells to the olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Reconstructing smell.Molecular neurobiology · 2000Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Expression of tyrosine hydroxylase (TH) by juxtaglomerular (JG) neurons of the olfactory bulb (OB) requires innervation of the bulb by olfactory receptor neurons (ORNs). ORN lesion selectively downregulates TH in JG neurons. In reversible odor deprivation, TH expression is downregulated as the naris is closed and then upregulated upon naris reopening. The mechanism or mechanisms regulating this dependence are unknown. TH expression could be regulated by trophic factor release and/or synaptic activity from ORN terminals. We investigated TH expression in cocultures of dissociated postnatal rat OB cells and embryonic olfactory neuroepithelium (OE) slice explants. TH-positive neurons in control dissociated OB cell cultures alone comprise only a small fraction of the total population of cells present in the culture. However, when OE slice explants are cocultured with dispersed OB cells, there is a mean 2.4-fold increase in the number of TH-positive neurons. ORNs in vivo use glutamate as a neurotransmitter. Broad spectrum excitatory amino acid antagonists (kyurenic acid) or selective antagonists of the NMDA receptor (APV) both prevent induction of TH expression in OE-OB cocultures. Furthermore, pulse application of NMDA stimulates TH expression in OB neurons in the absence of OE. In vitro, OB TH neurons express NMDA receptors, suggesting that NMDA stimulation is acting directly on TH neurons. Exposure of OE explants to natural odorants results in upregulation of TH, presumably through increased ORN activity, which could be blocked by APV. These findings indicate that odorant-stimulated glutamate release by ORN terminals regulates TH expression via NMDA receptors on JG dopaminergic neurons.
Indexed as
Identifiers
9952413PMC6786032W2167871684What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.