ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Mutation in neurofilament transgene implicates RNA processing in the pathogenesis of neurodegenerative disease.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 45 citations in OpenAlex.
- Posttranscriptional regulation of neurofilament proteins and tau in health and disease.Brain research bulletin · 2023Review
- Different Clinical Contexts of Use of Blood Neurofilament Light Chain Protein in the Spectrum of Neurodegenerative Diseases.Molecular neurobiology · 2020Review
- miRNA malfunction causes spinal motor neuron disease.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Aldolases a and C are ribonucleolytic components of a neuronal complex that regulates the stability of the light-neurofilament mRNA.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- The cytoskeleton in neurodegenerative diseases.The Journal of pathology · 2004Review
- 3' untranslated region in a light neurofilament (NF-L) mRNA triggers aggregation of NF-L and mutant superoxide dismutase 1 proteins in neuronal cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Untranslated element in neurofilament mRNA has neuropathic effect on motor neurons of transgenic mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Fending off decay: a combinatorial approach in intact cells for identifying mRNA stability elements.RNA (New York, N.Y.) · 2001Article
- Bcl-2 overexpression does not protect neurons from mutant neurofilament-mediated motor neuron degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A mouse neurofilament light subunit (NF-L) transgene with a 36 bp c-myc insert at the end of the coding region was found to have neuropathic effects on enteric and motor neurons of transgenic mice. The severity of phenotype was related directly to the levels of transgenic mRNA expression. High levels of transgene expression were lethal to newborn pups, causing profound alterations in the development of the enteric nervous system and extensive vacuolar changes in motor neurons. Lower levels of transgene expression led to a transient stunting of growth and focal alterations of enteric and motor neurons. Because the positioning of the c-myc insert coincided with the location of the major stability determinant of the NF-L mRNA (Cañete-Soler et al., 1998a,b), additional studies were undertaken. These studies showed that the c-myc insert alters the ribonucleoprotein (RNP) complexes that bind to the stability determinant and disrupts their ability to regulate the stability of the transcripts. The findings indicate that expression of an NF-L transgene with a mutant mRNA stability determinant is highly disruptive to enteric and motor neurons and implicate alterations in RNA processing in the pathogenesis of a neurodegenerative condition.
Indexed as
Identifiers
9952405PMC6786029W1741785399What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.