ArticleDigestive diseases and sciences1999
Reactions from rat gastric mucosa during one year of Helicobacter pylori infection.
Article in Digestive diseases and sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 52 citations in OpenAlex.
- Simple animal model of Helicobacter pylori infection.World journal of gastroenterology · 2014Article
- Helicobacter pylori promotes apoptosis, activates cyclooxygenase (COX)-2 and inhibits heat shock protein HSP70 in gastric cancer epithelial cells.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Angiotensin II receptor expression and relation to Helicobacter pylori-infection in the stomach of the Mongolian gerbil.BMC gastroenterology · 2010Article
- Effects of hypothalamic paraventricular nuclei on apoptosis and proliferation of gastric mucosal cells induced by ischemia/reperfusion in rats.World journal of gastroenterology · 2007Article
- Ligands for histamine H(3) receptors modulate cell proliferation and migration in rat oxyntic mucosa.British journal of pharmacology · 2002Article
- Attenuated apoptosis in H. pylori-colonized gastric mucosa of Mongolian gerbils in comparison with mice.Digestive diseases and sciences · 2002Article
- Helicobacter pylori strain-specific modulation of gastric mucosal cellular turnover: implications for carcinogenesis.Journal of gastroenterology · 2002Review
- A proinflammatory peptide from Helicobacter pylori activates monocytes to induce lymphocyte dysfunction and apoptosis.The Journal of clinical investigation · 2001Article
- Apoptosis induced by ischemia-reperfusion and fasting in gastric mucosa compared to small intestinal mucosa in rats.Digestive diseases and sciences · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to investigate responses from the gastric mucosa of rats during long-term H. pylori infection. Twenty-four Sprague-Dawley rats were inoculated with a mouse-adapted strain of human H. pylori (vacA+, cagA+), 16 uninfected rats served as controls. Three to six rats from each group were killed two weeks or two, six, or 12 months later. At sacrifice, blood was sampled and the gastric mucosa was taken for bacterial culture, histology, immunocytochemistry and in situ hybridization. H. pylori colonized the antrum in 23/24 inoculated rats; with time the density of bacteria increased. The inflammation in the antral mucosa was mild to moderate and was dominated by infiltration of lymphocytes and macrophages. Serum H. pylori-specific IgG2a was significantly increased in the infected rats. The frequency of epithelial cell apoptosis was significantly increased in the early months of infection. The mucosal expression of trefoil peptide mRNA remained unchanged. We conclude that after one year of H. pylori infection in rats, the mucosal responses were rather mild, indicating that the animals may adapt to the infection by mechanisms which remain to be identified.
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