ReviewDigestive diseases and sciences1999
Relationship of extraintestinal involvements in inflammatory bowel disease: new insights into autoimmune pathogenesis.
Review in Digestive diseases and sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 193 citations in OpenAlex.
- Diabetes mellitus, metformin's target gene AMPK, and inflammatory bowel disease: A Mendelian randomization study.Medicine · 2025Article
- The causal effects of inflammatory bowel disease on its ocular manifestations: A Mendelian randomization study.PloS one · 2025Article
- Factors Associated With Extraintestinal Manifestations of Inflammatory Bowel Disease in SPARC-IBD.Inflammatory bowel diseases · 2024Article
- Review
- Ophthalmological manifestations in inflammatory bowel disease under the watchful eye of a gastroenterologist from a tertiary centre.Przeglad gastroenterologiczny · 2024Article
- Inflammatory bowel disease and the associated risk of dry eye and ocular surface injury: a nationwide matched cohort study.BMC ophthalmology · 2023Article
- Inflammation, Autoinflammation and Autoimmunity in Inflammatory Bowel Diseases.Current issues in molecular biology · 2023Review
- Ocular Manifestations of Inflammatory Bowel Disease.Cureus · 2023Review
- Article
- New pattern of individualized management of chronic diseases: focusing on inflammatory bowel diseases and looking to the future.Frontiers in medicine · 2023Review
- Article
- Prevalence of extraintestinal manifestations in ulcerative colitis and associated risk factors.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Article
- Review
- Age and Gender: Affecting the Positive Rates of Serum PAB and ANCA in Patients with Inflammatory Bowel Disease.Gastroenterology research and practice · 2021Article
- MAdCAM-1 mediates retinal neuron degeneration in experimental colitis through recruiting gut-homing CD4Mucosal immunology · 2021Article
- Nasal mucosa pyoderma vegetans associated with ulcerative colitis: A case report.World journal of clinical cases · 2020Article
- Cutaneous manifestations in inflammatory bowel disease (Review).Experimental and therapeutic medicine · 2020Review
- Usefulness of magnetic resonance enterography in detecting signs of sacroiliitis in young patients with inflammatory bowel disease.Pediatric rheumatology online journal · 2020Article
- Risk factors associated with extraintestinal manifestations in children with inflammatory bowel disease.European journal of clinical nutrition · 2020Article
- Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Extraintestinal manifestations in patients with inflammatory bowel disease (IBD) are quite common (about 25%) and careful clinical observation and statistical analysis during the last five decades have demonstrated that in colitis-associated extraintestinal complications, the organs most commonly involved are the biliary tract, joints, skin, and eyes. However, almost all organs can be involved in IBD. Some of the extraintestinal manifestations may precede IBD, although the majority accompany the underlying disease and are influenced by its activity. Prompt recognition of extracolonic organ involvement in IBD is important because of the relative refractoriness of the disease and a possible increase in morbidity and mortality. The identified pathogenetic autoimmune mechanisms include genetic susceptibility, cytokine imbalances, antigenic display of autoantigen, aberrant self-recognition, and immunopathogenetic autoantibodies against organ-specific cellular antigen(s) shared by colon and extracolonic organs. Microbes may play an important role, probably by molecular mimicry.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.