ReviewImmunologic research1998
The immunopathology of siliconosis. History, clinical presentation, and relation to silicosis and the chemistry of silicon and silicone.
Review in Immunologic research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 52 citations in OpenAlex.
- Increased FGF-19 levels following explantation in women with breast implant illness.Scientific reports · 2025Article
- A Prospective Observational Clinical Cohort of Women with Suspected Breast Implant Illness.Journal of clinical medicine · 2024Article
- Silicone allergy associated with intraocular silicone ball prosthesis in a dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2021Article
- Dust Deposition Impacts at a Liquidated Gold Mine Village: Gauteng Province in South Africa.International journal of environmental research and public health · 2020Article
- Is explantation of silicone breast implants useful in patients with complaints?Immunologic research · 2017Review
- Breast implant-associated anaplastic large cell lymphoma: two distinct clinicopathological variants with different outcomes.Annals of oncology : official journal of the European Society for Medical Oncology · 2016Article
- The monobloc hydrogel breast implant, experiences and ideas.European journal of plastic surgery · 2012Article
- In vitro interactions between splenocytes and dansylamide dye-embedded nanoparticles detected by flow cytometry.Nanomedicine : nanotechnology, biology, and medicine · 2009Article
- Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases.Environmental health and preventive medicine · 2009Article
- The X and why of xenobiotics in primary biliary cirrhosis.Journal of autoimmunityReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence confirms the fundamental involvement of the human immune system in the reaction to implantation of silicone-based medical devices. An as yet-to-be particularized epitope of many complex substances sharing siloxane structures is presented through the MHC-II apparatus with development and retention of T cell memory. This memory can be tested for in practical terms using one or more forms of silica, which links the immuno-histopathology and autoimmune attributes of "silicosis" with those of "siliconosis." The lesions of siliconosis are typical of those for persistent antigens and delayed, cell mediated hypersensitivity. The basic descriptive pathology of the reaction to silicone has been known since soon after introduction of silicones in medical procedures, with the exception of some details related to the more recent discoveries on the role of cytokines in the immunopathic process. The clinical consequences of siliconosis are common and can be severe in some individuals implanted with silicone devices.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.