ArticleMolecular biology of the cell1999
The stem-loop binding protein (SLBP1) is present in coiled bodies of the Xenopus germinal vesicle.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Replication-dependent histone biosynthesis is coupled to cell-cycle commitment.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body.RNA biology · 2017Review
- A conserved interaction that is essential for the biogenesis of histone locus bodies.The Journal of biological chemistry · 2014Article
- Three-dimensional organisation of RNA-processing machinery in avian growing oocyte nucleus.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- Pearls are novel Cajal body-like structures in the Xenopus germinal vesicle that are dependent on RNA pol III transcription.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- Non-canonical Cajal bodies form in the nucleus of late stage avian oocytes lacking functional nucleolus.Histochemistry and cell biology · 2012Article
- Cajal body surveillance of U snRNA export complex assembly.The Journal of cell biology · 2010Article
- The Cajal body and histone locus body.Cold Spring Harbor perspectives in biology · 2010Review
- Review
- Review
- Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein.RNA (New York, N.Y.) · 2006Article
- U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis.RNA (New York, N.Y.) · 2006Article
- Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs.Genes & development · 2005Article
- Nuclear import of the stem-loop binding protein and localization during the cell cycle.Molecular biology of the cell · 2005Article
- Subnuclear localization and Cajal body targeting of transcription elongation factor TFIIS in amphibian oocytes.Molecular biology of the cell · 2003Article
- Stem-loop binding protein accumulates during oocyte maturation and is not cell-cycle-regulated in the early mouse embryo.Journal of cell science · 2002Article
- Lampbrush chromosomes and associated bodies: new insights into principles of nuclear structure and function.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2002Review
- Replication-dependent histone gene expression is related to Cajal body (CB) association but does not require sustained CB contact.Molecular biology of the cell · 2001Article
- Dual role for the RNA-binding domain of Xenopus laevis SLBP1 in histone pre-mRNA processing.RNA (New York, N.Y.) · 2000Article
- Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription.Genes & development · 2000Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The stem-loop binding protein (SLBP1) binds the 3' stem-loop of histone pre-mRNA and is required for efficient processing of histone transcripts in the nucleus. We examined the localization of SLBP1 in the germinal vesicle of Xenopus laevis oocytes. In spread preparations of germinal vesicle contents, an anti-SLBP1 antibody stained coiled bodies and specific chromosomal loci, including terminal granules, axial granules, and some loops. After injection of myc-tagged SLBP1 transcripts into the oocyte cytoplasm, newly translated myc-SLBP1 protein was detectable in coiled bodies within 4 h and in terminal and axial granules by 8 h. To identify the region(s) of SLBP1 necessary for subnuclear localization, we subcloned various parts of the SLBP1 cDNA and injected transcripts of these into the cytoplasm of oocytes. We determined that 113 amino acids at the carboxy terminus of SLBP1 are sufficient for coiled body localization and that disruption of a previously defined RNA-binding domain did not alter this localization. Coiled bodies also contain the U7 small nuclear ribonucleoprotein particle (snRNP), which participates in cleavage of the 3' end of histone pre-mRNA. The colocalization of SLBP1 and the U7 snRNP in the coiled body suggests coordinated control of their functions, perhaps through a larger histone-processing particle. Some coiled bodies are attached to the lampbrush chromosomes at the histone gene loci, consistent with the view that coiled bodies in the oocyte recruit histone-processing factors to the sites of histone pre-mRNA transcription. The non-histone chromosomal sites at which SLBP1 is found include the genes coding for 5 S rRNA, U1 snRNA, and U2 snRNA, suggesting a wider role for SLBP1 in the biosynthesis of small non-spliced RNAs.
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