ArticleMolecular biology of the cell1999
alpha1 and alpha2 integrins mediate invasive activity of mouse mammary carcinoma cells through regulation of stromelysin-1 expression.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 citations in OpenAlex.
- ITGA1 Promotes Glioma Cell Proliferation and Affects Immune Cell Infiltration in Low-Grade Glioma.Mediators of inflammation · 2024Article
- Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression.Reviews of physiology, biochemistry and pharmacology · 2021Review
- Reciprocal Interplay Between Fibrillar Collagens and Collagen-Binding Integrins: Implications in Cancer Progression and Metastasis.Frontiers in oncology · 2020Review
- Integrin α1 promotes tumorigenicity and progressive capacity of colorectal cancer.International journal of biological sciences · 2020Article
- Review
- Article
- Application of Synthetic Polymeric Scaffolds in Breast Cancer 3D Tissue Cultures and Animal Tumor Models.International journal of biomaterials · 2017Article
- Article
- A 3D matrix platform for the rapid generation of therapeutic anti-human carcinoma monoclonal antibodies.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Integrin α1 subunit is up-regulated in colorectal cancer.Biomarker research · 2013Article
- TNF-α promotes cerebral pericyte remodeling in vitro, via a switch from α1 to α2 integrins.Journal of neuroinflammation · 2013Article
- Article
- α6β4 integrin, a master regulator of expression of integrins in human keratinocytes.The Journal of biological chemistry · 2012Article
- Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung.Stem cells and development · 2011Article
- Characterization of a human cell line stably over-expressing the candidate oncogene, dual specificity phosphatase 12.PloS one · 2011Article
- Laminin induces matrix metalloproteinase-9 expression and activation in human cervical cancer cell line (SiHa).Journal of cancer research and clinical oncology · 2011Article
- Loss of the α2β1 integrin alters human papilloma virus-induced squamous carcinoma progression in vivo and in vitro.PloS one · 2011Article
- Autocrine semaphorin3A stimulates alpha2 beta1 integrin expression/function in breast tumor cells.Breast cancer research and treatment · 2009Article
- Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer.Cancer research · 2008Article
- Integrin dependence of Calu-1 cell motility on endothelial extracellular matrix proteins.Annals of biomedical engineering · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Tumor cell invasion relies on cell migration and extracellular matrix proteolysis. We investigated the contribution of different integrins to the invasive activity of mouse mammary carcinoma cells. Antibodies against integrin subunits alpha6 and beta1, but not against alpha1 and alpha2, inhibited cell locomotion on a reconstituted basement membrane in two-dimensional cell migration assays, whereas antibodies against beta1, but not against alpha6 or alpha2, interfered with cell adhesion to basement membrane constituents. Blocking antibodies against alpha1 integrins impaired only cell adhesion to type IV collagen. Antibodies against alpha1, alpha2, alpha6, and beta1, but not alpha5, integrin subunits reduced invasion of a reconstituted basement membrane. Integrins alpha1 and alpha2, which contributed only marginally to motility and adhesion, regulated proteinase production. Antibodies against alpha1 and alpha2, but not alpha6 and beta1, integrin subunits inhibited both transcription and protein expression of the matrix metalloproteinase stromelysin-1. Inhibition of tumor cell invasion by antibodies against alpha1 and alpha2 was reversed by addition of recombinant stromelysin-1. In contrast, stromelysin-1 could not rescue invasion inhibited by anti-alpha6 antibodies. Our data indicate that alpha1 and alpha2 integrins confer invasive behavior by regulating stromelysin-1 expression, whereas alpha6 integrins regulate cell motility. These results provide new insights into the specific functions of integrins during tumor cell invasion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.