ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne1999
Persistence with treatment for hypertension in actual practice.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
105 citing papers in PubMed, 316 citations in OpenAlex.
- 'New Medicine Service': supporting adherence in people starting a new medication for a long-term condition: 26-week follow-up of a pragmatic randomised controlled trial.BMJ quality & safety · 2020Trial
- Trial
- The Nigerian antihypertensive adherence trial: a community-based randomized trial.Journal of hypertension · 2013Trial
- Reducing clinical inertia in hypertension treatment: a pragmatic randomized controlled trial.Journal of clinical hypertension (Greenwich, Conn.) · 2012Trial
- Evaluation of a community pharmacy-based intervention for improving patient adherence to antihypertensives: a randomised controlled trial.BMC health services research · 2010Trial
- A cluster randomized trial to evaluate physician/pharmacist collaboration to improve blood pressure control.Journal of clinical hypertension (Greenwich, Conn.) · 2008Trial
- Management of patients with uncontrolled arterial hypertension--the role of electronic compliance monitoring, 24-h ambulatory blood pressure monitoring and Candesartan/HCTZ.BMC cardiovascular disorders · 2006Trial
- Effects of general practice-based nurse-counselling on ambulatory blood pressure and antihypertensive drug prescription in patients at increased risk of cardiovascular disease.Journal of human hypertension · 2003Trial
- Real-World Effectiveness and Safety of Ramipril/Indapamide Combination Therapy in Essential Hypertension: A Retrospective Study on UK Primary Care Records.International journal of hypertension · 2026Article
- Non-persistence to antihypertensive drug therapy in Lithuania.European journal of clinical pharmacology · 2022Article
- A Critical Review of Medication Adherence in Hypertension: Barriers and Facilitators Clinicians Should Consider.Patient preference and adherence · 2022Review
- The Impact of Treatment Adherence on Quality of Life Among Type 2 Diabetes Mellitus Patients - Findings from a Cross-Sectional Study.Patient preference and adherence · 2021Article
- Treatment Adherence to Nucleos(t)ide Analogs in Chinese Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma: A Single-Center Cross-Sectional Study.Patient preference and adherence · 2021Article
- Non-Adherence to Prescribed Antihypertensives in Primary, Secondary and Tertiary Healthcare Settings in Islamabad, Pakistan: A Cross-Sectional Study.Patient preference and adherence · 2020Article
- Using the transtheoretical model's stages of change to predict medication adherence in patients with type 2 diabetes mellitus in a primary health care setting.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2019Article
- Association between medication adherence and quality of life of patients with diabetes and hypertension attending primary care clinics: a cross-sectional survey.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Article
- Time to Filling of New Prescriptions for Chronic Disease Medications Among a Cohort of Elderly Patients in the USA.Journal of general internal medicine · 2018Article
- Comparison of Student and Patient Perceptions for Medication Non-adherence.American journal of pharmaceutical education · 2018Article
- A Novel Approach to Better Characterize Medication Adherence in Oral Anticancer Treatments.Frontiers in pharmacology · 2018Article
- Cost Effectiveness of Support for People Starting a New Medication for a Long-Term Condition Through Community Pharmacies: An Economic Evaluation of the New Medicine Service (NMS) Compared with Normal Practice.PharmacoEconomics · 2017Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the existence of efficacious medications, many patients in actual practice remain with uncontrolled hypertension. Randomized clinical trials, cannot address this issue well given their highly restricted environment. This paper examines persistence with antihypertensive therapy among patients in actual practice.
methodsCohort study of patients who received a diagnosis of hypertension and were treated between 1989 and 1994 identified through the Saskatchewan Health databases. Patients with concurrent diagnoses likely to affect initial treatment choice were excluded. The resulting population of 79,591 subjects was grouped into those with established hypertension (52,227 [66%]) and those with newly diagnosed hypertension (27,364 [34%]). The initial antihypertensive prescription, subsequent changes in treatment and persistence with antihypertensive therapy were analysed.
resultsPersistence with antihypertensive therapy decreased in the first 6 months after treatment was started and continued to decline over the next 4 years. Of the patients with newly diagnosed hypertension, only 78% persisted with therapy at the end of 1 year, as compared with 97% of the patients with established hypertension (p < 0.001). Among those with newly diagnosed hypertension, older patients were more likely than younger ones to persist, and women were more likely than men to persist (p < 0.001).
interpretationThis analysis of actual practice data indicates that barriers to persistence occur early in the therapeutic course and that achieving successful therapy when treatment is started is important to maintaining long-term persistence.
Indexed as
Identifiers
9934341PMC1229943W2132278229What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.