ArticleClinical and experimental immunology1999
Alterations in the number of circulating leucocytes, phenotype of monocyte and cytokine production in patients undergoing cardiothoracic surgery.
Article in Clinical and experimental immunology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 68 citations in OpenAlex.
- Early expression of FcgammaRI (CD64) on monocytes of cardiac surgical patients and higher density of monocyte anti-inflammatory scavenger CD163 receptor in "on-pump" patients.Mediators of inflammation · 2008Trial
- HLA-DR as a marker for increased risk for systemic inflammation and septic complications after cardiac surgery.Intensive care medicine · 2003Trial
- Perioperative GLY-GLN infusion diminishes the surgery-induced period of immunosuppression: accelerated restoration of the lipopolysaccharide-stimulated tumor necrosis factor-alpha response.Annals of surgery · 2003Trial
- A New Easy-to-Perform Flow Cytometry Assay for Determining Bacterial- and Viral-Infection-Induced Polymorphonuclear Neutrophil and Monocyte Membrane Marker Modulation in Febrile Patients.International journal of molecular sciences · 2024Article
- Longitudinal profiling in patients undergoing cardiac surgery reveals postoperative changes in DNA methylation.Clinical epigenetics · 2022Article
- Cardiac surgery outcomes in patients with coronavirus disease 2019 (COVID-19): A case-series report.The Journal of thoracic and cardiovascular surgery · 2022Article
- Infection with the SARS-CoV-2 Omicron variant in children with congenital heart disease: A case series study during Shanghai epidemic.Frontiers in cardiovascular medicine · 2022Article
- Eotaxin-2 induces monocytic apoptosis in patients who have undergone coronary artery bypass surgery and in THP-1 cellsAmerican journal of translational research · 2018Article
- A Thrombomodulin Gene Polymorphism (C1418T) Is Associated with Early Outcomes in Patients Undergoing Coronary Artery Bypass Graft Surgery with a Conventional Cardiopulmonary Bypass during Hospitalization.Medicines (Basel, Switzerland) · 2017Article
- Migration of CD11b+ accessory cells during murine lung regeneration.Stem cell research · 2013Article
- Comparison of the clinical application of reactive oxygen species and inflammatory markers in patients with endocarditis.Archives of medical science : AMS · 2012Article
- High-sensitivity C-reactive protein (hs-CRP) and tumor necrotizing factor-alpha (TNF-alpha) after on- and off- pump coronary artery bypass grafting.HSR proceedings in intensive care & cardiovascular anesthesia · 2010Article
- Hsp70 and cardiac surgery: molecular chaperone and inflammatory regulator with compartmentalized effects.Cell stress & chaperones · 2009Review
- Immune response of severely injured patients--influence of surgical intervention and therapeutic impact.Langenbeck's archives of surgery · 2007Review
- Pleural macrophages are the dominant cell population in the thoracic cavity with an inflammatory cytokine profile similar to peritoneal macrophages.Pediatric surgery international · 2007Article
- Is monocyte HLA-DR expression predictive for clinical outcome in sepsis?Intensive care medicine · 2003Article
- Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass.Clinical and experimental immunology · 2001Article
- Haemodialysis monocytopenia: differential sequestration kinetics of CD14+CD16+ and CD14++ blood monocyte subsets.Clinical and experimental immunology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in the differential blood cell count, monocyte phenotype and the cytokine plasma levels in a group of seven patients with cardiac surgery/cardiopulmonary bypass (CPB) and nine patients with thoracic surgery/without CPB, both receiving identical opioid-based anaesthetic technique, were assessed. A significant reduction in the number of circulating lymphocytes and monocytes was observed after anaesthesia and surgery. Interestingly, at the end of surgery as well as 1 day post-surgery a marked increase in the number of granulocytes was noted. General anaesthesia and surgery caused a significant reduction of HLA-DR and CD11c/CD18 molecules, starting immediately after induction of anaesthesia, and an increase of CD64 at day 1 after anaesthesia. The use of a CPB was followed by a significant reduction of CD32, CD16, CD54 and HLA-ABC antigens expression at the end of surgery. One day after surgery these parameters returned nearly to baseline values with the exception of CD54. A monocyte subpopulation, characterized by low CD14, high CD16 and HLA-DR expression (CD14+CD16+HLA-DR++) was found in both groups at each time point, and the percentage of this cell subset decreased from baseline to 24 h. The plasma concentrations of IL-6 and IL-10 increased considerably during CPB. No dynamic changes of IL-1 level due to surgery or CPB were found. We conclude that anaesthesia as well as the use of CPB induced profound alterations in the number of circulating leucocytes, and in the phenotype of monocyte and cytokine production.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.